Rule-dependent shifting of sensorimotor representation in the primate prefrontal cortex
Rule-dependent shifting of sensorimotor representation in the primate prefrontal cortex
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DOI：
10.1111/j.1460-9568.2006.04702.x
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发表时间：
2006-04-01
影响因子：
3.4
通讯作者：
Sawaguchi, T
中科院分区：
文献类型：
--
作者：
Amemori, K;Sawaguchi, T
当我们对外部世界做出反应时，感知到的感官信息通常会在一段时间内被记忆下来，然后根据行为规则转化为运动指令。在这种基于记忆的感觉运动转换中，工作记忆被认为起着重要的作用。研究表明，外侧前额叶皮层参与了工作记忆的加工过程。然而，从工作记忆中引导运动指令的神经元机制尚未建立。为了研究视觉空间工作记忆是如何与即将到来的眼跳方向，我们使用了一个antisaccade范式的猴子，其中的行为规则是在中间的延迟期。在这项任务中，受试者被要求保持线索的位置，并选择一个基于行为规则的反应。我们发现，在外侧前额叶皮层的记忆神经元的子集改变了他们的代表线索眼跳方向。此外，这些神经元的眼跳方向的辨别力往往出现后不久的行为规则介绍，表明他们的行为规则的显着依赖。这些结果表明，在外侧前额叶皮层记忆神经元的一个子集改变他们的活动取决于一个行为规则，以指导一个前瞻性的运动命令。
When we react to the outer world, perceived sensory information is frequently memorized over a temporal interval then transformed into a motor command based on a behavioural rule. In this type of memory-based sensorimotor transformation, working memory is considered to play an important role. It has been suggested that the lateral prefrontal cortex is involved in the process of the working memory. However, the neuronal mechanism for guiding a motor command from the working memory has not been established. To examine how visuospatial working memory is linked with a forthcoming saccade direction, we used an antisaccade paradigm for monkeys in which a behavioural rule was presented in the middle of a delay period. In this task, the subjects were required to maintain cue location and to select a response based on a behavioural rule. We found that a subset of mnemonic neurons in the lateral prefrontal cortex changed their representation from cue to saccade direction. Furthermore, the discriminability for saccade direction of these neurons tended to appear soon after the behavioural rule presentation, indicating their significant dependency on the behavioural rule. These results suggest that a subset of mnemonic neurons in the lateral prefrontal cortex change their activity depending on a behavioural rule to guide a prospective motor command.