Oryzias curvinotus has DMY, a gene that is required for male development in the medaka, O. latipes
Oryzias curvinotus has DMY, a gene that is required for male development in the medaka, O. latipes
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DOI：
10.2108/zsj.20.159
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发表时间：
2003-02-01
影响因子：
0.9
通讯作者：
Sakaizumi, M
中科院分区：
文献类型：
--
作者：
Matsuda, M;Sato, T;Sakaizumi, M
DMY 是雄性发育所需的 Y 特异性 DM 结构域基因，似乎是硬骨鱼青鳉 Oryzias latipes 中的性别决定基因。尽管含有 DMY 的基因组区域似乎起源于 DMRT1 区域的复制，但复制发生的时间尚不清楚。在这里，我们发现O. curvinotus的Y染色体上也有DMY基因，该基因与青鳉的Y染色体同源，并且DMY在XY胚胎中表达。基于包括 DIM 结构域的氨基酸序列的系统发育树表明，在 O. latipes 和 O. curvinotus 物种形成之前，DMY 源自 DMRT1。
DMY is a Y-specific DM-domain gene required for male development and appears to be the sex-determining gene in the teleost fish medaka, Oryzias latipes. Although the genomic region containing DMY appears to have originated through duplication of the DMRT1 region, it is unknown when the duplication occurred. Here we show that O. curvinotus also has the DMY gene on the Y chromosome, which is homologous to the Y chromosome of medaka, and that DMY is expressed in XY embryos. A phylogenetic tree based on the amino acid sequence including the DIM-domain shows that DMY was derived from DMRT1 immediately before speciation of O. latipes and O. curvinotus.