Enhancement of MR images using registration for signal averaging
Enhancement of MR images using registration for signal averaging
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DOI：
10.1097/00004728-199803000-00032
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发表时间：
1998-03-01
影响因子：
1.3
通讯作者：
Evans, AC
中科院分区：
文献类型：
--
作者：
Holmes, CJ;Hoge, R;Evans, AC
目的：随着非侵入性神经影像学的出现，大量的数字化人类神经解剖图谱已经被开发出来。这些地图集的准确性受到现有成像设备的分辨率和信号收集能力的限制。在试图规避这些限制，并产生一个高分辨率在体内人体神经解剖学，我们调查的有用性intrasobject注册事后的MR信号averaging.Method：27高分辨率（7 × 0.78和20 × 1.0毫米（3））T1加权体积从一个单一的主题，沿着与12双回波T2/质子密度加权体积。这些体积被自动配准到一个共同的立体定位空间，在其中它们被二次采样和强度平均。所得到的图像进行检查的解剖质量和其他分析technology.Results的有用性：所得到的图像的质量从组合少至五个T1体积明显增强。预期信噪比随着贡献扫描次数的根增加至5.2，n = 27。n = 27的平均改善足够大，精细的解剖细节，如丘脑亚核和尾状核与壳核之间的灰色桥，变得清晰明确。灰/白色物质边界也增强，被不同T1强度的组织包围的任何更精细结构的可见性也增强。T2和质子密度平均图像也比单次扫描的质量更高，但改善不显着的T1 volumes.Conclusion：总体而言，平均图像中的增强信号导致更高质量的解剖图像，数据借给自己的几个后处理技术。高质量的增强图像允许新的数据使用，并扩展了体内人类神经解剖学的可能性。
Purpose: With the advent of noninvasive neuroimaging, a plethora of digital human neuroanatomical atlases has been developed. The accuracy of these atlases is constrained by the resolution and signal-gathering powers of available imaging equipment. In an attempt to circumvent these limitations and to produce a high resolution in vivo human neuroanatomy, we investigated the usefulness of intrasubject registration for post hoc MR signal averaging.Method: Twenty-seven high resolution (7 x 0.78 and 20 x 1.0 mm(3)) T1-weighted volumes were acquired from a single subject, along with 12 double echo T2/proton density-weighted volumes. These volumes were automatically registered to a common stereotaxic space in which they were subsampled and intensity averaged. The resulting images were examined for anatomical quality and usefulness for other analytical techniques.Results: The quality of the resulting image from the combination of as few as five T1 volumes was visibly enhanced. The signal-to-noise ratio was expected to increase as the root of the number of contributing scans to 5.2, n = 27. The improvement in the n = 27 average was great enough that fine anatomical details, such as thalamic subnuclei and the gray bridges between the caudate and putamen, became crisply defined. The gray/white matter boundaries were also enhanced, as was the visibility of any finer structure that was surrounded by tissue of varying T1 intensity. The T2 and proton density average images were also of higher quality than single scans, but the improvement was not as dramatic as that of the T1 volumes.Conclusion: Overall, the enhanced signal in the averaged images resulted in higher quality anatomical images, and the data lent themselves to several postprocessing techniques. The high quality of the enhanced images permits novel uses of the data and extends the possibilities for in vivo human neuroanatomy.