Performance of the Cockcroft-Gault, MDRD, and New CKD-EPI Formulas in Relation to GFR, Age, and Body Size
Performance of the Cockcroft-Gault, MDRD, and New CKD-EPI Formulas in Relation to GFR, Age, and Body Size
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DOI：
10.2215/cjn.06870909
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发表时间：
2010-06-01
影响因子：
9.8
通讯作者：
Krediet, Raymond Theodorus
中科院分区：
文献类型：
--
作者：
Michels, Wieneke Marleen;Grootendorst, Diana Carina;Krediet, Raymond Theodorus
背景和目的：我们比较了Cockcroft-Gault、肾脏疾病饮食改变（MDRD）和慢性肾脏疾病流行病学合作（CKD-EPI）方程的估计与使用i -125-碘甲酸酯的金标准GFR测量，在GFR、性别、年龄、体重和体重指数（BMI）的层面上。设计、设置、参与者和测量：对于以前接受过GFR测量的人，在变量的分层内计算测量和估计肾功能之间的偏差、精度和准确度。用线性回归分析检验绝对偏差与各变量之间的关系。结果：总体而言(n = 271, 44%男性，平均测量GFR 72.6 ml/min / 1.73 m(2) [SD 30.4 ml/min / 1.73 m(2)])， MDRD的平均偏倚最小（P < 0.01）。CKD-EPI的准确性最高（与Cockcroft-Gault比较P < 0.01），与MDRD无差异（P = 0.14）。所有公式的绝对偏倚与年龄有关。对于MDRD和CKD-EPI，绝对偏倚也与GFR相关；对于Cockcroft-Gault来说，它也与体重和BMI有关。在所有极端亚组中，MDRD和CKD-EPI提供了最高的准确性。结论：各配方的绝对偏倚均受年龄的影响；CKD-EPI和mdr也受GFR的影响。Cockcroft-Gault还受体重和BMI的影响。一般来说，CKD-EPI给出了最好的GFR估计，尽管它的准确性接近MDRD。中华临床医学杂志，2010,29(5):391 - 391。doi: 10.2215 / CJN.06870909
Background and objectives: We compared the estimations of Cockcroft-Gault, Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations to a gold standard GFR measurement using I-125-iothalamate, within strata of GFR, gender, age, body weight, and body mass index (BMI).Design, setting, participants, & measurements: For people who previously underwent a GFR measurement, bias, precision, and accuracies between measured and estimated kidney functions were calculated within strata of the variables. The relation between the absolute bias and the variables was tested with linear regression analysis.Results: Overall (n = 271, 44% male, mean measured GFR 72.6 ml/min per 1.73 m(2) [SD 30.4 ml/min per 1.73 m(2)]), mean bias was smallest for MDRD (P < 0.01). CKD-EPI had highest accuracy (P < 0.01 compared with Cockcroft-Gault), which did not differ from MDRD (P = 0.14). The absolute bias of all formulas was related to age. For MDRD and CKD-EPI, absolute bias was also related to the GFR; for Cockcroft-Gault, it was related to body weight and BMI as well. In all extreme subgroups, MDRD and CKD-EPI provided highest accuracies.Conclusions: The absolute bias of all formulas is influenced by age; CKD-EPI and MDRD are also influenced by GFR. Cockcroft-Gault is additionally influenced by body weight and BMI. In general, CKD-EPI gives the best estimation of GFR, although its accuracy is close to that of the MDRD. Clin J Am Soc Nephrol 5: 1003-1009, 2010. doi: 10.2215/CJN.06870909