NERVE-TERMINAL MORPHOLOGY IN C57BL/6NNIA MICE AT DIFFERENT AGES
NERVE-TERMINAL MORPHOLOGY IN C57BL/6NNIA MICE AT DIFFERENT AGES
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DOI：
10.1093/geronj/44.2.b43
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发表时间：
1989-03-01
期刊：
影响因子：
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通讯作者：
FAHIM, MA
中科院分区：
文献类型：
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作者：
ANDONIAN, MH;FAHIM, MA
哺乳动物神经肌肉接头（NMJ）似乎经历一个动态的重塑过程，随着年龄的增长。以前的研究表明，NMJ随着年龄的增长而逐渐变大，在快肌中的程度比慢肌更大。为了更好地理解这一过程，对来自4、8、10、12、18、22、24和32个月龄的C57 BL/6 NNia小鼠的比目鱼肌和趾长伸肌（EDL）神经末梢进行定量形态测量。计算机辅助形态测量的相机lucida图纸的老化神经末梢表明显着差异的大小和复杂性的NMJ在两个肌肉之间的不同年龄组，但是，有没有显着的净趋势与年龄。形态变化的幅度和方向取决于特定的年龄比较，并发生在更大程度上的EDL。这项研究是第一次在这么多年龄对C57 BL/6 NNia神经末梢进行全面的形态计量学研究。结果与Fischer 344大鼠的结果相似，并支持神经末梢重塑是一个动态过程而非渐进性过程的假设。
The mammalian neuromuscular junction (NMJ) appears to undergo a dynamic remodeling process with advancing age. Previous studies suggest that the NMJ becomes progressively larger with age, to a greater degree in fast-twitch muscles than slow-twitch muscles. To better understand this process, quantitative morphometry was conducted on soleus and extensor digitorum longus (EDL) nerve terminals from C57BL/6NNia mice aged 4, 8, 10, 12, 18, 22, 24, and 32 months. Computer-aided morphometry of camera lucida drawings of aging nerve terminals indicated significant differences in the size and complexity of NMJs in both muscles between different age groups; however, there were no significant net trends with age. The magnitude and direction of the morphometric changes depended on the particular ages compared, and occurred to a greater degree in the EDL. This study is the first comprehensive morphometric study of C57BL/6NNia nerve terminals at so many ages. The results are similar to those obtained for the Fischer 344 rat, and support the hypothesis that nerve terminal remodeling is a dynamic process, not a progressive elaboration.