Magnetisation transfer saturation (MTsat) and MTR: relationship with T1 recovery in multiple sclerosis and healthy brain
Magnetisation transfer saturation (MTsat) and MTR: relationship with T1 recovery in multiple sclerosis and healthy brain
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磁化转移饱和度 (MTsat) 和 MTR：与多发性硬化症和健康大脑中 T1 恢复的关系
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通讯作者：
A. Waldman
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作者：
E. York;R. Meijboom;A. Kampaite;Maria Valdes Hernandez;M. Thrippleton;A. Waldman
由于T1校正，磁化传递饱和度（MTsat）与磁化传递比（MTR）相比显示出改善的组织对比度，并且对多发性硬化症（MS）中的细微髓鞘丢失更敏感。目前尚不清楚MTsat如何在T1显著增加的严重脱髓鞘组织中发挥作用。我们研究了T1app，MTsat和MTR在健康和MS大脑之间的关系。我们显示了白色物质中MTsat和T1app之间的负线性关系，其在灰质和白色物质病变中分解。MTsat对中度髓鞘破坏敏感，而T1app可能更好地反映MS病变中的严重损伤。
Magnetisation transfer saturation (MTsat) shows improved tissue contrast compared with magnetisation transfer ratio (MTR), due to T1 correction, and is more sensitive to subtle myelin loss in multiple sclerosis (MS). It is not clear how MTsat performs in severely demyelinated tissue with markedly increased T1. We examine the relationship between T1app, MTsat and MTR in healthy and MS brains. We show a negative linear relationship between MTsat and T1app in white matter, which breaks down in grey matter and white matter lesions. MTsat is sensitive to modest myelin disruption, while T1app may better reflect severe damage in MS lesions.