Direct phenotypical and functional dysregulation of primary human B cells by human immunodeficiency virus (HIV) type 1 in vitro.
Direct phenotypical and functional dysregulation of primary human B cells by human immunodeficiency virus (HIV) type 1 in vitro.
复制标题
DOI：
10.1371/journal.pone.0039472
复制
发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Pion M
中科院分区：
文献类型：
--
作者：
Perisé-Barrios AJ;Muñoz-Fernandez MÁ;Pion M
Human immunodeficiency virus type 1 (HIV-1) induces a general dysregulation of immune system. Dysregulation of B cell compartment is generally thought to be induced by HIV-related immune activation and lymphopenia. However, a direct influence of HIV-1 particles on B cells was recently proposed as the third pathway of B cells dysregulation. We evaluated the direct and specific consequences of HIV-1 contact on activation, survival, proliferation and phenotype of primary B cells in vitro. Moreover, we examined expression of activation-induced cytidine deaminase (AID) mRNA that is responsible for class switch recombination (CSR) and somatic hypermutation (SHM). Here, we report that changes observed in cellular proliferation, phenotypes and activation of B cells could be caused by direct contact between HIV-1 particles and primary B cells in vitro. Finally, direct HIV-1-derived B cells activation led to the increase of AID mRNA expression and its subsequent CSR function was detected in vitro. We showed that HIV-1 could directly induce primary B cells dysregulation triggering phenotypical and functional abilities of B cells in vitro that could explain in some extent early B-cell abnormalities in HIV disease.
登录
查看更多内容
DOI：
10.1084/jem.192.5.637
发表时间：
2000-09-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Moir S;Malaspina A;Li Y;Chun TW;Lowe T;Adelsberger J;Baseler M;Ehler LA;Liu S;Davey RT Jr;Mican JA;Fauci AS
通讯作者：
Fauci AS
DOI：
10.1097/00126334-200212150-00003
发表时间：
2002-12-15
影响因子：
3.6
作者：
Jacobson, MA;Khayam-Bashi, H;Ng, V
通讯作者：
Ng, V
DOI：
10.1073/pnas.181347898
发表时间：
2001-08-28
影响因子：
11.1
作者：
Moir, S;Malaspina, A;Fauci, AS
通讯作者：
Fauci, AS
影响因子：
15.3
作者：
Moir, Susan;Ho, Jason;Fauci, Anthony S.
通讯作者：
Fauci, Anthony S.
影响因子：
3.7
作者：
Cagigi, Alberto;Du, Likun;Nilsson, Anna
通讯作者：
Nilsson, Anna