Feline Immunodeficiency Virus Neuropathogenesis: A Model for HIV-Induced CNS Inflammation and Neurodegeneration.
Feline Immunodeficiency Virus Neuropathogenesis: A Model for HIV-Induced CNS Inflammation and Neurodegeneration.
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DOI：
10.3390/vetsci4010014
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发表时间：
2017-03-06
影响因子：
2.4
通讯作者：
Hudson L
中科院分区：
文献类型：
--
作者：
Meeker RB;Hudson L
猫免疫缺陷病毒（FIV）与其人类免疫缺陷病毒（HIV）类似，在感染后很快进入中枢神经系统（CNS）并建立一个受保护的病毒库。随之而来的炎症和损伤引起不同程度的认知能力下降，统称为hiv相关神经认知障碍（HAND）。由于与HIV感染和疾病的相似性，FIV为体外和体内研究CNS感染、炎症和病理提供了有用的模型。这篇综述总结了从早期感染、免疫细胞运输、炎症和神经发病机制的研究中获得的见解。我们对这些过程的理解的进步促进了旨在保护神经元和调节炎症活动的治疗干预的发展。
Feline Immunodeficiency virus (FIV), similar to its human analog human immunodeficiency virus (HIV), enters the central nervous system (CNS) soon after infection and establishes a protected viral reservoir. The ensuing inflammation and damage give rise to varying degrees of cognitive decline collectively known as HIV-associated neurocognitive disorders (HAND). Because of the similarities to HIV infection and disease, FIV has provided a useful model for both in vitro and in vivo studies of CNS infection, inflammation and pathology. This mini review summarizes insights gained from studies of early infection, immune cell trafficking, inflammation and the mechanisms of neuropathogenesis. Advances in our understanding of these processes have contributed to the development of therapeutic interventions designed to protect neurons and regulate inflammatory activity.