Chlorpromazine-induced systemic lupus erythematosus: case report and review of the literature.

Chlorpromazine-induced systemic lupus erythematosus: case report and review of the literature.
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氯丙嗪诱发的系统性红斑狼疮：病例报告和文献综述。

DOI：
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发表时间：
1972
期刊：
Journal of the American Medical Association (JAMA)
影响因子：
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通讯作者：
R. A. Wonka
R. A. Wonka
中科院分区：
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文献类型：
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作者：
E. Dubois;E. Tallman;R. A. Wonka

文献摘要

被引文献

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一位38岁男性在每日服用氯丙嗪400毫克17个月后出现多关节炎、光敏感蝴蝶区皮疹、胸腔积液、白细胞减少和发热。存在红斑狼疮（LE）细胞和抗核抗体（ANA）。停药后，在两周内出现改善;在36小时内用氯丙嗪激发后症状复发。停药2个月后LE细胞和ANA消失。
A 38-year-old man developed polyarthritis, light-sensitive butterfly area eruption, pleurisy with effusion, leukopenia, and fever after taking 400 mg of chlorpromazine daily for 17 months. Lupus erythematosus (LE) cells and antinuclear antibodies (ANA) were present. Following cessation of the medication, improvement occurred within two weeks; symptoms recurred on challenging with chlorpromazine within 36 hours. The LE cells and ANA disappeared two months after the drug was withdrawn.