Developmental aspects and neurobiological correlates of working and associative memory.
Developmental aspects and neurobiological correlates of working and associative memory.
复制标题
工作记忆和联想记忆的发育方面和神经生物学相关性。
DOI：
10.1037/neu0000053
复制
发表时间：
2014
期刊：
影响因子：
2.4
通讯作者：
Pettegrew,JayW
中科院分区：
文献类型：
--
作者：
Goldstein,Gerald;Allen,DanielN;Thaler,NicholasS;Luther,JamesF;Panchalingam,Kanagasabai;Pettegrew,JayW
目的已经表明，言语工作和联想记忆与工作记忆具有不同的发展轨迹，从幼儿期到青春期呈线性过程，而联想记忆则呈曲线过程，在 12 岁时渐近。本研究确定了这些轨迹是否与 2 个磁共振波谱成像 (MRSI) 变量：磷酸肌酸水平 (PCr) 和灰质百分比 (GM%) 一致。方法在一项横断面研究中， 94 名年龄在 6 至 14 岁之间的儿童接受了言语工作和联想记忆测试，并接受了 MRSI 程序评估 6 个主要大脑区域。该研究考虑了 6 个地区的 PCr 水平和 GM%。构建 Loess 曲线，绘制随年龄变化的记忆测试和 MRSI 变量，并对轨迹进行评估。结果 PCr 显示出随年龄的线性增加，特别是在左上颞叶，这种增加密切跟踪工作记忆的改善，但不跟踪联想记忆得分的改善。任何大脑区域的 GM% 均不随年龄而增加，并且任何一项记忆测试都没有跟踪。 结论 言语工作记忆和言语联想记忆具有不同的年龄轨迹，工作记忆与 PCr 水平密切相关，主要在左上颞叶。联想记忆测试中没有发现这样的跟踪。各地区的 GM% 曲线平坦，与年龄无关。
ObjectiveIt has been shown that verbal working and associative memory have different developmental trajectories with working memory, taking a linear course from early childhood to adolescence, whereas associative memory takes a curvilinear course asymptoting at about age 12. This study made a determination of whether these trajectories tracked with 2 magnetic resonance spectroscopy imaging (MRSI) variables: phosphocreatine level (PCr) and gray matter percentage (GM%).MethodIn a cross-sectional study, 94 children ranging in age from 6–14 years were administered tests of verbal working and associative memory and underwent an MRSI procedure evaluating 6 major brain regions. The study considered PCr levels and GM% in the 6 regions. Loess curves were constructed plotting the memory tests and MRSI variables across age, and trajectories were evaluated.ResultsPCr showed a linear increase with age, particularly in the left superior temporal lobe with this increase closely tracking improvement in working memory but not associative memory scores. GM% did not increase with age in any brain region, and there was no tracking with either of the memory tests.ConclusionVerbal working memory and verbal associative memory have differing age trajectories, with working memory showing close tracking with PCr level, mainly in the left superior temporal lobe. No such tracking was found for the associative memory tests. GM% curves were flat across regions, showing no association with age.