Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in vitro REV1 inserts dC opposite the lesion and DNA polymerase k potentially catalyzes extension reaction from the 3'-dC terminus.
Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in vitro REV1 inserts dC opposite the lesion and DNA polymerase k potentially catalyzes extension reaction from the 3'-dC terminus.
复制标题
体外通过 2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶 (PhIP) 的 C8-鸟苷加合物进行跨病灶 DNA 合成 REV1 在病灶对面插入 dC,并且 DNA 聚合酶 k 可能催化来自病灶的延伸反应
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发表时间:
2009
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et al.
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作者:
Fukuda;et al.