Cytokine expression in lupus kidneys
Cytokine expression in lupus kidneys
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DOI：
10.1191/0961203305lu2053oa
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发表时间：
2005-01-01
期刊：
影响因子：
2.6
通讯作者：
Smolen, JS
中科院分区：
文献类型：
--
作者：
Aringer, M;Smolen, JS
虽然远未完成，但系统性红斑狼疮（SLE）肾小球肾炎中存在的细胞因子的情况已经很复杂。促炎细胞因子如TNF、IL-6、IL-1和IL-18被上调，Th 1和Th 2细胞因子也是如此，具有不同的含义。在许多情况下，局部效应可能与全身免疫调节效应不同。对于某些促炎细胞因子，特别是TNF，局部促炎细胞因子可能与疾病更相关。这可能有助于解决疾病的不同小鼠模型之间的差异，并为靶向人类SLE中的某些细胞因子提供更好的理论基础。
Although far from complete, the picture of cytokines present in systemic lupus erythematosus (SLE) glomerulonephritis is already complex. Proinflammatory cytokines, such as TNF, IL-6, IL-1, and IL-18 are upregulated, as are both Th1 and Th2 cytokines, with different implications. In many instances, the local effects may be different from the systemic immunoregulatory ones. For some proinflammatory cytokines, and TNF in particular, the local proinflammatory ones may be more relevant to the disease. This may help solve discrepancies between different murine models of the disease and provide a better rationale for targeting certain cytokines in human SLE.