Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder
Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder
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DOI：
10.1016/j.nicl.2017.08.001
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发表时间：
2017-01-01
影响因子：
4.2
通讯作者：
van der Wee, Nic J. A.
中科院分区：
文献类型：
--
作者：
Bas-Hoogendam, Janna Marie;van Steenbergen, Henk;van der Wee, Nic J. A.
社交焦虑障碍（SAD）是一种流行的致残性精神障碍，与显著的精神共病相关。以往对SAD相关脑结构改变的研究，在不同脑区灰质（GM）变化的方向以及脑结构与SAD相关性之间的关系上，得出了不一致的结果。这些异质性结果可能是由于样本量有限。多位点成像提供了新的机会，调查SAD相关的脑结构的改变，在更大的samples.An国际多中心大型分析SAD结构T1加权3 T MRI扫描的最大数据库，到目前为止，进行比较GM的SAD患者（n = 174）和健康对照（HC）的参与者（n = 213）使用基于体素的形态测量体积。采用假设驱动的感兴趣区（ROI）方法，重点关注基底神经节、杏仁核-海马复合体、前额叶皮质和顶叶皮质。SAD患者有较大的GM体积在背侧纹状体相比，HC参与者。这种增加与自我报告的社交焦虑症状的严重程度呈正相关。在其他ROI中，GM体积没有SAD相关差异。因此，这个大分析的结果表明，背侧纹状体在SAD中的作用，但先前报道的SAD相关的变化，在杏仁核，海马，楔前叶，前额叶皮层和顶叶区的GM没有复制。我们的研究结果强调了大样本影像学研究的重要性，并需要进行荟萃分析，如通过荟萃分析增强神经影像遗传学（ENIGMA）联盟进行的荟萃分析。
Social anxiety disorder (SAD) is a prevalent and disabling mental disorder, associated with significant psychiatric comorbidity. Previous research on structural brain alterations associated with SAD has yielded inconsistent results concerning the direction of the changes in graymatter (GM) in various brain regions, as well as on the relationship between brain structure and SAD-symptomatology. These heterogeneous findings are possibly due to limited sample sizes. Multisite imaging offers new opportunities to investigate SAD-related alterations in brain structure in larger samples.An international multi-center mega-analysis on the largest database of SAD structural T1-weighted 3T MRI scans to date was performed to compare GM volume of SAD-patients (n = 174) and healthy control (HC)-participants (n = 213) using voxel-based morphometry. A hypothesis-driven region of interest (ROI) approach was used, focusing on the basal ganglia, the amygdala-hippocampal complex, the prefrontal cortex, and the parietal cortex. SAD-patients had larger GM volume in the dorsal striatum when compared to HC-participants. This increase correlated positively with the severity of self-reported social anxiety symptoms. No SAD-related differences in GM volume were present in the other ROIs. Thereby, the results of this mega-analysis suggest a role for the dorsal striatum in SAD, but previously reported SAD-related changes in GM in the amygdala, hippocampus, precuneus, prefrontal cortex and parietal regions were not replicated. Our findings emphasize the importance of large sample imaging studies and the need for meta-analyses like those performed by the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium.