CYTOKINES IN HUMAN INTRAOCULAR INFLAMMATION
CYTOKINES IN HUMAN INTRAOCULAR INFLAMMATION
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DOI：
10.3109/02713689208999531
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发表时间：
1992-01-01
影响因子：
2
通讯作者：
DUMONDE, DC
中科院分区：
文献类型：
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作者：
FRANKS, WA;LIMB, GA;DUMONDE, DC
本研究探讨白细胞介素6（IL-6）、白细胞介素1（IL-1）、白细胞介素2（IL-2）和肿瘤坏死因子（TNF）在玻璃体切除术治疗不同炎症性疾病的患者玻璃体和房水吸出物中的存在。10例正常人的尸体玻璃体作为对照。在5例特发性葡萄膜炎眼标本中检测到IL-6（范围= 26-264 pg/ml），2例葡萄膜炎合并视网膜脱离的标本（分别为28和279 pg/ml），来自糖尿病视网膜病变眼的6个样本中（范围= 5-480 pg/ml），在来自患有晶状体溶解性青光眼的眼睛的一个样品中（1190 pg/ml）和在来自患有白塞氏病的眼睛的一个样本中（366 pg/ml）。尽管在80%的所有研究样品中检测到IL-1，但仅在来自葡萄膜炎眼睛的2个样品（分别为5和20 pg/ml）和来自糖尿病视网膜病变眼睛的2个样品（分别为3和31 pg/ml）中观察到该细胞因子的浓度>3 pg/ml。TNF存在于3个葡萄膜炎眼的样本中（范围= 2-24 pg/ml）和1个糖尿病视网膜病变眼的样本中（4 pg/ml），但在晶状体溶解性青光眼或白塞病眼中未检测到。IL-2（
The presence of interleukin 6 (IL-6), interleukin 1 (IL-1), interleukin 2 (IL-2) and tumour necrosis factor (TNF) was investigated in vitreous and aqueous aspirates from eyes undergoing vitrectomy for the treatment of different inflammatory conditions. Cadaveric vitreous from 10 normal subjects were used as controls. IL-6 was observed in 5 specimens from eyes with idiopathic uveitis (range = 26-264 pg/ml), in 2 specimens from eyes with uveitis complicated with retinal detachment (28 and 279 pg/ml, respectively), in 6 samples from eyes with diabetic retinopathy (range = 5-480 pg/ml), in one sample from an eye with phacolytic glaucoma (1190 pg/ml) and in one specimen from an eye with Behcet's disease (366 pg/ml). Although IL-1 was detected in 80% of all the samples investigated, concentrations of this cytokine >3 pg/ml were only observed in 2 specimens from eyes with uveitis (5 and 20 pg/ml, respectively) and 2 samples from eyes with diabetic retinopathy (3 and 31 pg/ml, respectively). TNF was present in 3 specimens from eyes with uveitis (range = 2-24 pg/ml) and 1 sample from eyes with diabetic retinopathy (4 pg/ml), but was not detected in the eyes with phacolytic glaucoma or Behcet's disease. IL-2 (