Associations Between Bone Mineral Density and Subclinical Atherosclerosis: A Cross-Sectional Study of a Chinese Population
Associations Between Bone Mineral Density and Subclinical Atherosclerosis: A Cross-Sectional Study of a Chinese Population
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骨矿物质密度与亚临床动脉粥样硬化之间的关联：中国人群的横断面研究
DOI：
10.1210/jc.2013-2572
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发表时间：
2014-02-01
影响因子：
5.8
通讯作者：
Chen, Xiang-Mei
中科院分区：
文献类型：
--
作者：
Liang, Dong-Ke;Bai, Xiao-Juan;Chen, Xiang-Mei
内容：在亚洲人群中骨密度（BMD）和动脉粥样硬化之间的关联的意义尚不清楚。目的：本研究的目的是探讨BMD和亚临床动脉粥样硬化之间的人群水平的关联。设计和设置：这是一项在中国沈阳进行的以社区为基础的横断面研究。参与者：共385名年龄在37-87岁的中国女性和男性进行了研究。主要结果测量：使用双能X线骨密度仪测量全髋关节和腰椎的BMD。测量踝臂指数（ABI）、脉搏波传导速度（PWV）和颈动脉内膜中层厚度（CIMT）以评估动脉粥样硬化。采用多元回归分析方法研究两者之间的关系。使用方差膨胀因子、条件指数和方差比例检验多元线性。结果：BMD正常组、骨量减少组和骨质疏松组的ABI、PWV和CIMT差异均无统计学意义，女性全髋BMD与ABI经年龄校正后呈显著正相关（r = 0.156）。性别特异性回归模型包括年龄、体重指数、吸烟、饮酒、绝经状态（女性）、收缩压、舒张压、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、空腹血糖、血清尿酸、估计肾小球滤过率、高敏C反应蛋白和纤维蛋白原的校正。调整年龄后，女性全髋BMD与ABI相关（ABI每标准差下降：-0.130 g/cm（2），P = 0.022），但完全调整后，该相关性为临界显著性（P = 0.045）。在对无骨折史的受试者进行充分校正后，全髋BMD和腰椎BMD与ABI、PWV和CIMT无关。骨质疏松症的风险与ABI，PWV和CIMT无关。结论：低BMD与ABI，PWV和CIMT评估的亚临床动脉粥样硬化无关。
Context: The significance of associations between bone mineral density (BMD) and atherosclerosis in the Asian population is less clear.Objective: The aim of this study was to explore the population-level associations between BMD and subclinical atherosclerosis.Design and Setting: This was a community-based cross-sectional study conducted in Shenyang, China.Participants: A total of 385 Chinese women and men aged 37-87 years were studied.Main Outcome Measures: The BMD was measured at the total hip and lumbar spine using dual-energy x-ray absorptiometry. The ankle-brachial index (ABI), pulse wave velocity (PWV), and carotid intima-media thickness (CIMT) were measured to assess atherosclerosis. Multiple regression analysis was applied to study the associations. Multicolinearity was examined using the variance inflation factor, condition index, and variance proportions. Factor analysis and principal component regression were used to remove the problem of multicolinearity.Results: The differences of ABI, PWV, and CIMT among the normal BMD, osteopenia, and osteoporosis groups were not found. Total hip BMD was correlated with ABI in women after adjustment for age (r = 0.156). Sex-specific regression models included adjustment for age, body mass index, cigarette smoking, alcohol consumption, menopausal status (women), systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting blood glucose, serum uric acid, estimated glomerular filtration rate, high-sensitivity C-reactive protein, and fibrinogen. Total hip BMD was associated with ABI in women after adjustment for age (per SD decrease in ABI: -0.130 g/cm(2), P = .022), but the association was borderline significant after full adjustment (P = .045). Total hip BMD and lumbar spine BMD were not associated with ABI, PWV, and CIMT after full adjustment in participants without a fracture history. The risk of osteoporosis was not associated with ABI, PWV, and CIMT.Conclusions: Low BMD is not associated with subclinical atherosclerosis as assessed by ABI, PWV, and CIMT.