Experimental Transplantation of Carcinoma to Tooth Extraction Sockets : A bone invasion model
Experimental Transplantation of Carcinoma to Tooth Extraction Sockets : A bone invasion model
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癌移植至拔牙槽的实验性移植：骨侵袭模型
DOI：
10.3353/omp.8.61
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
A. Irie
中科院分区：
文献类型：
--
作者：
Hideki Takahashi;T. Inokuchi;H. Ikeda;J. Sekine;A. Irie
本研究的目的是描述口腔癌侵袭骨的过程。将小鼠NR-S1肿瘤或人培养的NB-1肿瘤移植到拔牙槽内，建立口腔癌侵袭颌骨的实验模型。肿瘤移植后早期，肿瘤在拔牙槽内生长，随后填充拔牙槽并向外扩展至邻近区域。研究肿瘤侵袭过程中骨吸收、胶原蛋白生成情况及HSP47表达情况。破骨细胞早期在相应骨表面出现增多，随着骨吸收和肿瘤侵袭的进展，破骨细胞数量逐渐减少。肿瘤附近的骨内可见增大的骨腔隙以及Haversian和Volkmann管，增大的骨腔内也可见肿瘤细胞。HSP47在浸润到骨组织的癌细胞中表达阳性，而在肿块中表达阴性。总之，细胞可能通过溶骨间隙侵入骨，需要周围的ECM来增殖其营养供应。
The purpose of this study was to delineate the process of bone invasion by oral carcinoma. An experimental model of oral carcinoma invading jawbone was established by transplanting mouse NR-S1 tumor or human-cultured NB-1 tumor to the tooth extraction socket. In the early stage after tumor transplantation, the tumor grew in the extraction socket and subsequently filled the socket and extended outward to the neighboring regions. Bone resorption and collagen production status, as well as HSP47 expression, were investigated in the process of the tumor invasion. Osteoclasts appeared increasingly on the surface of the corresponding bone during the early stage and then decreased in number as bone resorption with tumor invasion progressed. Enlarged osseous lacunae, as well as Haversian and Volkmann's canals, were present in the bone near the tumor, and tumor cells were also detected in the enlarged osseous spaces. Expression of HSP47 was positive for the carcinoma cells infiltrating into the bone tissue, but not for the counterparts in the mass. In summary, cells may invade bone through the osteolytic spaces and necessitate ECM around them for their nutritional supply to proliferate.
通过抑制 C57 BL/6 小鼠的促纤维增生反应，增加 BL6 黑色素瘤的侵袭和自发转移。
影响因子：
11.2
作者：
Barsky,SH;Gopalakrishna,R
通讯作者：
Gopalakrishna,R
影响因子：
11.2
作者：
S. Aznavoorian;Bryan A. Moore;L. D. Alexander-Lister;S. Hallit;L. Windsor;Jeffrey A. Engler
通讯作者：
S. Aznavoorian;Bryan A. Moore;L. D. Alexander-Lister;S. Hallit;L. Windsor;Jeffrey A. Engler