ELECTRICAL TRANSMISSION AT EXCITATORY SYNAPSE IN VERTEBRATE BRAIN
ELECTRICAL TRANSMISSION AT EXCITATORY SYNAPSE IN VERTEBRATE BRAIN
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DOI：
10.1126/science.144.3620.878
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发表时间：
1964-01-01
期刊：
影响因子：
56.9
通讯作者：
FURSHPAN, EJ
中科院分区：
文献类型：
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作者：
FURSHPAN, EJ
在金鱼的骨髓中发现了一种在脊椎动物大脑中新颖的兴奋性突触传递。某些突触终末（Bartelmez的俱乐部末梢）似乎通过其动作电流穿过突触膜的被动传播来刺激Mauthner神经元（M细胞）。刺激同侧第八脑神经后，M细胞内出现兴奋性突触后电位（EPSP），其潜伏期很短（约0.1毫秒），可能是一个可以忽略的突触延迟。这种反应归因于M细胞的棒状末梢，在活动期间，沿M细胞的侧树突沿着存在陡峭的电位梯度，并且早期EPSP在棒状末梢占优势的树突的远端部分最大。M细胞的潜在变化（被动地）向后传播到某些第八神经纤维（可能是俱乐部末梢），表明它们与M细胞之间存在特殊的低电阻连接。
A type of excitatory synaptlc transmission which is novel for the vertebrate brain has been found in the medulla of the goldfish. Certain synaptic terminals (the club endings of Bartelmez) appear to stimulate the Mauthner neuron (M-cell) by means of the passive spread of their action currents across the synaptlc membrane. After stimulating the ipsi-lateral eighth cranial nerve, an excitatory postysynaptic potential (EPSP) appears in the M-cell with a latency which is very brief (about 0.1 msec) and which probably represents a negligible synaptic delay. This response is attributed to the club endings there were steep gradients of potential along the lateral dendrite of the M-cell during activity and the early EPSP was maximal in the distal part of the dendrite where the club endings predominate. Potential changes in the M-cell spread (passively) backwards into certain eighth-nerve fibers (probably club endings) indicating the presence of special low-resistance connections between them and the M-cell.