The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models.
The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models.
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DOI：
10.4103/1319-3767.173753
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Stanciu C
中科院分区：
文献类型：
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作者：
Balmus IM;Ciobica A;Trifan A;Stanciu C
炎症性肠病（IBD），包括克罗恩病（CD）和溃疡性结肠炎（UC），是一种慢性炎症性疾病，其特征在于临床复发和缓解的交替阶段。IBD的病因在很大程度上仍然未知，尽管患者的免疫应答、遗传学、微生物组和环境的组合在扰乱肠道稳态中起着重要作用，导致IBD中炎症级联的发展和持续。由于慢性肠道炎症与活性氧和活性氮物质（ROS和RNS）的形成有关，因此氧化和亚硝化应激已被认为是IBD发展的主要促成因素之一。大量证据表明，IBD与ROS增加和抗氧化活性降低之间的失衡相关，这可能至少部分解释CD和UC患者的许多临床病理生理学特征。在此，我们回顾了目前已知的氧化剂和抗氧化剂参与IBD特异性事件的机制，用于确定这些特定功能的动物模型，以及IBD患者的抗氧化剂治疗。
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disorder characterized by alternating phases of clinical relapse and remission. The etiology of IBD remains largely unknown, although a combination of patient's immune response, genetics, microbiome, and environment plays an important role in disturbing intestinal homeostasis, leading to development and perpetuation of the inflammatory cascade in IBD. As chronic intestinal inflammation is associated with the formation of reactive oxygen and reactive nitrogen species (ROS and RNS), oxidative and nitrosative stress has been proposed as one of the major contributing factor in the IBD development. Substantial evidence suggests that IBD is associated with an imbalance between increased ROS and decreased antioxidant activity, which may explain, at least in part, many of the clinical pathophysiological features of both CD and UC patients. Hereby, we review the presently known oxidant and antioxidant mechanisms involved in IBD-specific events, the animal models used to determine these specific features, and also the antioxidant therapies proposed in IBD patients.