Developmental and hormonal regulation of the sex difference in preprotachykinin gene expression in rat anterior pituitaries.
Developmental and hormonal regulation of the sex difference in preprotachykinin gene expression in rat anterior pituitaries.
复制标题
大鼠垂体前叶前速激肽基因表达性别差异的发育和激素调节。
DOI：
10.1111/j.1749-6632.1991.tb33088.x
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发表时间：
1991
影响因子：
5.2
通讯作者：
Leeman,SE
中科院分区：
文献类型：
--
作者：
Jonassen,JA;Leeman,SE
速激肽肽，物质P（SP）和神经激肽A（NU，也称为物质K），由前速激肽原（PPT）蛋白前体产生，由PPT基因编码。初级PPT mRNA转录物被差异加工成三种成熟PPT mRNA：a、p和y。在大鼠中，分别编码SP和NKA的p-和y-PPT mRNA占主导地位：SP和NKA存在于大鼠垂体前叶中2”我们以前的工作”最近证实PPT基因在大鼠垂体前叶中表达，表明该组织是速激肽合成的场所。青春期后，雄性大鼠垂体前叶SP和NKA含量高于雌性大鼠垂体前叶。'"'^.腺垂体中PPT mRNA的一个可比较的差异7表明，速激肽浓度的性别差异是由PPT基因表达的性别差异引起的。
The tachykinin peptides, substance P (SP) and neurokinin A (NU, also called substance K), are generated from a preprotachykinin (PPT) protein precursor, encoded by the PPT gene.'-'The primary PPT mRNA transcript is differentially processed into three mature PPT mRNAs: a, p, and y. I4 In the rat, the p-and y-PPT mRNAs, each encoding SP and NKA, are predominant: SP and NKA are present in rat anterior pituitary glandss2" Our previous work," recently confirmed by demonstrated that the PPT gene is expressed in rat anterior pituitary, suggesting that this tissue is a site of tachykinin synthesis. After puberty, male rat anterior pituitaries have more SP and NKA than do anterior pituitaries of female rat^.^.^.'"'^.'^ A comparable difference in adenohypophyseal PPT mRNAI7 suggests that sex differenccs in tachykinin concentrations arise from sex differences in PPT gene expression.