Complexes of dichloro[2-(dimethylaminomethyl)phenyl-C1, N]gold(III), [Au(damp-C1,N)Cl2],with formylferrocene thiosemicarbazones:: synthesis, structure and cytotoxicity
Complexes of dichloro[2-(dimethylaminomethyl)phenyl-C1, N]gold(III), [Au(damp-C1,N)Cl2],with formylferrocene thiosemicarbazones:: synthesis, structure and cytotoxicity
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DOI：
10.1016/j.jinorgbio.2004.02.019
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发表时间：
2004-06-01
影响因子：
3.9
通讯作者：
Abram, U
中科院分区：
文献类型：
--
作者：
Casas, JS;Castaño, MV;Abram, U
二氯[2-(二乙氨基甲基)苯基-C-1，N]金(III)，[Au(DAMP-C-1，N)Cl-2]与由4-甲基，4-苯基，4-乙基-和4，4-二甲基-3-氨基硫脲衍生的甲酰基二茂铁缩氨基硫脲反应，得到通式为[Au(HDamp-C-1)Cl(FcTSC)]Cl的配合物。通过元素分析、质谱学和IR、H-1、C-13核磁共振等手段对化合物进行了结构表征。在某些情况下，循环伏安研究表明，金的络合作用影响了二茂铁单元的氧化还原行为。对可溶性较强的络合物也进行了体外抗肿瘤活性的测定。IC50值高于顺铂，但最大抗增殖活性相近。(C)2004 Elsevier Inc.保留所有权利。
Dichloro[2-(diniethylaminomethyl)phenyl-C-1,N]gold(III), [Au(damp-C-1,N)Cl-2], reacts with the formylferrocene thiosemicarbazones derived from 4-methyl-, 4-phenyl-, 4-ethyl- and 4,4-dimethyl-3-thiosemicarbazides, HFcTSC, to give complexes of general formula [Au(Hdamp-C-1)Cl(FcTSC)]Cl. These complexes were isolated and characterized by elemental analysis, mass spectrometry and IR, H-1 NMR and C-13 NMR spectroscopy. In some cases, cyclic voltammetric studies were carried out and these showed that the complexation of gold affects the redox behaviour of the ferrocene unit. The in vitro antitumor activity against the HeLa cell line was also determined for the more soluble complexes. The IC50 values were found to be higher than that of cisplatin but the maximum antiproliferative activity was similar. (C) 2004 Elsevier Inc. All rights reserved.