A DIALLEL ANALYSIS OF NICOTINE-INDUCED HYPOTHERMIA
A DIALLEL ANALYSIS OF NICOTINE-INDUCED HYPOTHERMIA
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DOI：
10.1016/s0091-3057(84)80079-9
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发表时间：
1984-01-01
影响因子：
3.6
通讯作者：
COLLINS, AC
中科院分区：
文献类型：
--
作者：
MARKS, MJ;MINER, L;COLLINS, AC
小鼠在急性注射尼古丁后出现的体温过低反应显示出遗传影响。注射0.75或1.5 mg/kg尼古丁后，所有5种供试品系小鼠的体温均降低，但C3 H品系小鼠的影响小于DBA、BALB或C57 BL品系小鼠。A系小鼠对尼古丁的作用最敏感。尼古丁诱导的体温过低的遗传效应进一步研究使用5 × 5双杂交。两种尼古丁剂量下均出现加性遗传变异。大量的显性差异，包括定向优势向一个大的低体温反应诱导注射低剂量的尼古丁（0.75毫克/公斤），表明一个强烈的反应，低剂量的药物是适应性的。高剂量（1.5 mg/kg）给药后，方向优势消失。上位性相互作用发生在涉及C57 BL小鼠的交叉是明显的。
The hypothermic responses of mice that occur after acute injection of nicotine show genetic influences. The body temperatures of mice of all 5 strains tested decreased after injection of either 0.75 or 1.5 mg/kg nicotine, but mice of the C3H strain were less affected than were those of the DBA, BALB or C57BL strains. Mice of the A strain were the most sensitive to nicotine''s effects. Genetic effects on nicotine-induced hypothermia were further examined using a 5-by-5 diallel cross. Additive genetic-variance occurred at both nicotine doses. Substantial dominance variance, including directional dominance toward a large hypothermic response induced by injection of a low dose of nicotine (0.75 mg/kg), suggested that an intense response to a low drug dose is adaptive. The directional dominance was absent after treatment with a high dose (1.5 mg/kg) of the drug. Epistatic interactions occurring in crosses involving C57BL mice were pronounced.