Olfactory dysfunction in schizophrenia and temporal lobe epilepsy.
Olfactory dysfunction in schizophrenia and temporal lobe epilepsy.
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发表时间：
2001-04
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通讯作者：
C. Kohler;P. Moberg;R. Gur;M. O’Connor;M. Sperling;R. Doty
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作者：
C. Kohler;P. Moberg;R. Gur;M. O’Connor;M. Sperling;R. Doty
背景精神分裂症和内侧颞叶癫痫（TLE）是两种常见的脑部疾病，它们都具有颞叶边缘神经基质功能障碍。目的评价精神分裂症患者的嗅觉表现是否与左侧或右侧颞叶癫痫患者相似。方法对40例精神分裂症患者、14例右颞叶癫痫患者、18例左颞叶癫痫患者和25例健康对照者进行气味辨别能力和检测阈值灵敏度的测定。气味识别进行了评估与宾夕法尼亚大学的气味识别测试（UPSIT）和气味检测阈值灵敏度与一个单一的阶梯程序，使用兴奋剂苯乙醇（PEA）。结果与对照组相比，只有精神分裂症和右颞叶癫痫患者表现出显着损害的UPSIT性能。左颞叶癫痫患者和对照组在UPSIT上进行了电刺激。四组间对PEA的检测阈值敏感性无显著差异。结论：这些数据表明嗅觉加工对右半球结构的依赖性更大，也与最近的神经影像学研究相一致，这些研究表明精神分裂症患者右半球脑区的嗅觉信息加工异常。
BACKGROUND Schizophrenia and mesial temporal lobe epilepsy (TLE) represent two common brain disorders that share dysfunction of temporo-limbic neural substrates. OBJECTIVE We evaluated whether patients with schizophrenia exhibited olfactory performance more similar to right or left temporal lobe epilepsy patients. METHODS Odor identification ability and detection threshold sensitivity were measured in 40 patients with schizophrenia, 14 patients with right- and 18 patients with left-temporal lobe epilepsy (TLE) patients, and 25 healthy controls. Odor identification was assessed with the University of Pennsylvania Smell Identification Test (UPSIT) and odor detection threshold sensitivity with a single-staircase procedure using the stimulant phenyl ethyl alcohol (PEA). RESULTS Relative to controls, only patients with schizophrenia and right TLE exhibited significant impairment in UPSIT performance. Left TLE patients and controls performed comparably on the UPSIT. Detection threshold sensitivity to PEA did not differ significantly among the four groups. CONCLUSIONS These data suggest a greater reliance of olfactory processing on right hemisphere structures and are also consistent with recent neuroimaging studies that have implicated aberrant processing of olfactory information in right hemispheric brain regions in schizophrenia.