EFFECTS OF NICOTINIC AND MUSCARINIC COMPOUNDS ON BITING ATTACK IN CAT
EFFECTS OF NICOTINIC AND MUSCARINIC COMPOUNDS ON BITING ATTACK IN CAT
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DOI：
10.1016/0091-3057(76)90072-1
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发表时间：
1976-01-01
影响因子：
3.6
通讯作者：
WALKER, JM
中科院分区：
文献类型：
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作者：
BERNTSON, GG;BEATTIE, MS;WALKER, JM
在正常无攻击性的猫中，系统给药毒蕈碱激动剂槟榔碱（7-12 mg/kg）后，会引起对老鼠的掠食性咬咬攻击，以及发出嘶嘶声、咆哮和其他威胁行为。与槟榔碱相反，尼古丁抑制了攻击行为。在注射槟榔碱之前，全身给予尼古丁（0.5 mg/kg）可显著减少引发的攻击和威胁行为。尼古丁（0.075 ~ 0.500 mg/kg）对自然捕食行为也产生剂量依赖性抑制。这种尼古丁产生的发作抑制似乎不是由于全身不适的诱导，因为发作抑制可以在没有一般行为抑制的情况下看到，并且导致发作完全抑制的尼古丁剂量对食物摄入量几乎没有影响。毒蕈碱和烟碱类化合物可以对某些类型的攻击行为施加拮抗控制。
Predatory-like biting attack on a rat, as well as hissing, growling and other threat behaviors, could be induced in normally non-aggressive cats by systemic administration of the muscarinic agonist, arecoline (7-12 mg/kg). In contrast to arecoline, nicotine suppressed aggressive behaviors. Systemic administration of nicotine (0.5 mg/kg) prior to arecoline injection resulted in a significant reduction in elicited attack and threat behaviors. Nicotine (0.075-0.500 mg/kg) produced a dose-dependent suppression of natural predatory behavior as well. This nicotine-produced suppression of attack did not appear to be due to the induction of general malaise, since attack suppression could be seen in the absence of general behavioral inhibition, and doses of nicotine resulting in complete suppression of attack had little effect on food intake. Muscarinic and nicotinic compounds can exert antagonistic control over some types of aggressive behaviors.