Sickle cell anemia patients have low erythropoietin levels for their degree of anemia.
Sickle cell anemia patients have low erythropoietin levels for their degree of anemia.
复制标题
DOI：
10.1182/blood.v67.1.46.bloodjournal67146
复制
发表时间：
1986
期刊：
影响因子：
20.3
通讯作者：
J. Sherwood;E. Goldwasser;R. Chilcote;L. Carmichael;R. Nagel
中科院分区：
文献类型：
--
作者：
J. Sherwood;E. Goldwasser;R. Chilcote;L. Carmichael;R. Nagel
我们研究了28例无肾功能不全的镰状细胞性贫血（SCA）患者和17例严重程度相当的非血红蛋白病性贫血患者的血清免疫反应性促红细胞生成素（SIE）水平。所有患者的SIE水平与贫血程度呈指数关系。然而，在非血红蛋白病性贫血中，当血红蛋白（Hb）水平降至约12 g/dL以下时，SIE水平急剧升高，而在镰状细胞患者中，直到血红蛋白降至约9 g/dL时，SIE水平才显著升高。老年SCA患者的反应比年轻患者更迟钝。SIE水平与Hb水平、SCA存在/不存在和年龄相关的线性回归模型解释了SIE变化的63%。我们的结论是，SCA的血清促红细胞生成素水平增加在较低的血红蛋白浓度，是一个较低的幅度比其他贫血。
We have studied serum immunoreactive erythropoietin (SIE) levels in 28 patients with sickle cell anemia (SCA) without renal insufficiency and in 17 patients with nonhemoglobinopathy anemias of comparable severity using a sensitive radioimmunoassay procedure. An exponential relationship between SIE level and degree of anemia was noted in all patients. However, in nonhemoglobinopathy anemia, a sharp rise in the SIE level occurred as hemoglobin (Hb) levels fell below about 12 g/dL, whereas in sickle cell patients the increase was not marked until hemoglobin fell to about 9 g/dL. The response was more blunted in older SCA patients than in younger ones. A linear regression model relating SIE level to Hb level, presence/absence of SCA, and age explained 63% of the variation in SIE. We conclude that the serum erythropoietin levels in SCA increased at a lower hemoglobin concentration and are of a lower magnitude than that of the other anemias.