DIASTEREOSELECTIVE ALKYLATION OF 3-ACYLIMIDAZOLIDIN-2-ONES - SYNTHESIS OF (R)-LAVANDULOL AND (S)-LAVANDULOL
DIASTEREOSELECTIVE ALKYLATION OF 3-ACYLIMIDAZOLIDIN-2-ONES - SYNTHESIS OF (R)-LAVANDULOL AND (S)-LAVANDULOL
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DOI：
10.1021/jo00245a043
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发表时间：
1988-05-13
影响因子：
3.6
通讯作者：
SANDRI, S
中科院分区：
文献类型：
--
作者：
CARDILLO, G;DAMICO, A;SANDRI, S
与我们的一般interestin寻找新的方法异戊二烯化合物，1我们开发了一个程序，将一个异戊二烯单元的时间，通过烷基化的锂二价阴离子的3-甲基-2-丁烯酸。2 34这种方法提供了具有la-vandulyl骨架的萜烯，因为这种二价阴离子主要在C-2.3，4进行烷基化。由于光学活性单萜烯的重要性日益增加，5通过手性助剂的不对称合成引起了人们的兴趣。6
In connection with our general interestin the search for new approaches toprenyl compounds, 1 we developed a procedure incorporating one prenyl unit at a time, through the alkylation of the Li dianion of 3-methyl-2-butenoic acid. 2 34This methodology provides terpenes with the la-vandulyl skeleton, since this dianion undergoes alkylation predominantly at C-2.3, 4 Owing to the increasing importance of optically active monoterpenes, 5 their asym-metric synthesis through chiral auxiliaries has attracted interest. 6