Oxytocin increases autonomic cardiac control: Moderation by loneliness
Oxytocin increases autonomic cardiac control: Moderation by loneliness
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DOI：
10.1016/j.biopsycho.2010.11.006
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发表时间：
2011-03-01
影响因子：
2.6
通讯作者：
DeVries, A. Courtney
中科院分区：
文献类型：
--
作者：
Norman, Greg J.;Cacioppo, John T.;DeVries, A. Courtney
目前的研究探讨了社会孤立感在调节催产素对人类心脏自主控制的影响中的作用。鼻内给药20 IU催产素导致自主神经（副交感神经和交感神经）心脏控制的显着增加。具体来说，催产素增加高频心率变异性，一个相对纯粹的测量副交感神经心脏控制，并减少射血前期，增强交感神经心脏控制的一个验证良好的标记。自主合作和互惠的衍生指标显示，催产素显着增加整体自主心脏控制。此外，催产素对心脏自主控制的影响与孤独等级显著相关。更高水平的孤独感与副交感神经对鼻内催产素的反应性降低有关。OT对自主心脏控制的影响独立于对循环促炎细胞因子或应激激素水平的任何影响。因此，孤独的个体可能对催产素对心血管反应性的有益效果反应较低。(C)2010 Elsevier B.V.保留所有权利。
The current study examined the role of perceived social isolation in moderating the effects of oxytocin on cardiac autonomic control in humans. Intranasal administration of 20 IU oxytocin resulted in a significant increase in autonomic (parasympathetic and sympathetic) cardiac control. Specifically, oxytocin increased high frequency heart rate variability, a relatively pure measure of parasympathetic cardiac control, and decreased pre-ejection period, a well-validated marker of enhanced sympathetic cardiac control. Derived metrics of autonomic co-activity and reciprocity revealed that oxytocin significantly increased overall autonomic cardiac control. Furthermore, the effects of oxytocin on cardiac autonomic control were significantly associated with loneliness ratings. Higher levels of loneliness were associated with diminished parasympathetic cardiac reactivity to intranasal oxytocin. The effects of OT on autonomic cardiac control were independent of any effects on circulating pro-inflammatory cytokine or stress hormone levels. Thus, lonely individuals may be less responsive to the salubrious effects of oxytocin on cardiovascular responsivity. (C) 2010 Elsevier B.V. All rights reserved.