Review: Lutheran/B-CAM: A laminin receptor on red blood cells and in various tissues
Review: Lutheran/B-CAM: A laminin receptor on red blood cells and in various tissues
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DOI：
10.1080/03008200500344074
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发表时间：
2005-01-01
影响因子：
2.9
通讯作者：
Miner, JH
中科院分区：
文献类型：
--
作者：
Kikkawa, Y;Miner, JH
Lutheran血型糖蛋白（Lu），也称为基底细胞粘附分子（B-CAM），是一种跨膜受体，在其细胞外区域具有五个免疫球蛋白样结构域;因此它被分类为免疫球蛋白（1g）基因家族的成员。Lu/B-CAM不仅在红细胞上观察到，而且在各种组织中的肌肉和上皮细胞的子集上观察到。最近，几个研究小组报道Lu/B-CAM是层粘连蛋白α 5的新型受体。层粘连蛋白α 5链是层粘连蛋白-511（α 5 β 1 γ 1）、-521（α 5 β 2 γ 1）和-523（α 5 β 2 γ 3）异源三聚体的组分;并在整个哺乳动物体内表达。我们还表明Lu/B-CAM与层粘连蛋白a5在各种组织中共定位。虽然Lu/B-CAM的生物学作用仍不清楚，但Lu/B-CAM与层粘连蛋白α 5的特异性结合表明其在发育和生理过程中起重要作用。还需要进一步研究Lu/B-CAM和层粘连蛋白α 5在病理过程（包括镰状细胞病和癌症）中的相互作用。
The Lutheran blood group glycoprotein (Lu), also known as basal cell adhesion molecule (B-CAM), is a transmembrane receptor with five immunoglobulin-like domains in its extracellular region; it is therefore classified as a member of the immunoglobulin (1g) gene family. Lu/B-CAM is observed not only on red blood cells, but also on a subset of muscle and epithelial cells in various tissues. Recently, several groups have reported that Lu/B-CAM is a novel receptor for laminin alpha 5. The laminin alpha 5 chain is a component of the laminin-511 (alpha 5 beta 1 gamma 1), -521 (alpha 5 beta 2 gamma 1), and -523 (alpha 5 beta 2 gamma 3) heterotrimers; and is expressed throughout the mammalian body. We also have shown that Lu/B-CAM is co-localized with laminin a5 in various tissues. Although the biological role of Lu/B-CAM remains unclear, the specific binding of Lu/B-CAM to laminin alpha 5 suggests that it plays an important role in developmental and physiological processes. It also is necessary to investigate further the interaction between Lu/B-CAM and laminin alpha 5 in pathological processes, including sickle cell disease and cancer.