A model of coccidioidal meningoencephalitis and cerebrospinal vasculitis in the rabbit.
A model of coccidioidal meningoencephalitis and cerebrospinal vasculitis in the rabbit.
复制标题
兔球孢子菌脑膜脑炎和脑脊髓血管炎模型。
DOI：
10.1086/515689
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Stevens,DA
中科院分区：
文献类型：
--
作者：
Williams,PL;Sobel,RA;Sorensen,KN;Clemons,KV;Shuer,LM;Royaltey,SS;Yao,Y;Pappagianis,D;Lutz,JE;Reed,C;River,ME;Lee,BC;Bhatti,SU;Stevens,DA
球孢子菌脑膜炎是播散性球孢子菌病的破坏性并发症。这种感染的动物模型可以增强对该疾病发病机制的了解并改进治疗方法。采用盲池穿刺技术，将 4 × 103−1 × 106 球孢子菌节分孢子接种于小脑池，建立模拟人类疾病的兔中枢神经系统感染模型。在所有兔子中均观察到脑膜炎的全身、神经学和组织病理学结果，但接种 2 × 104 节分孢子会产生慢性疾病，其中始终观察到闭塞性脑膜动脉内膜炎。脑脊液的连续取样显示出炎症反应。 C. 生长通过大脑和近端脊髓的定量真菌培养证明了immitis。
Coccidioidal meningitis is a devastating complication of disseminated coccidioidomycosis. An animal model of this infection could enhance understanding of the pathogenesis of the disease and lead to improvements in therapy. A rabbit model of central nervous system infection simulating human disease was established using a blind cisternal tap technique to inoculate 4 × 103−1 × 106arthroconidia ofCoccidioides immitisinto the cisterna magna. Systemic, neurologic, and histopathologic findings of meningitis were observed in all rabbits, but an inoculum of 2 × 104arthroconidia produced a chronic illness in which meningeal endarteritis obliterans was consistently observed. Serial sampling of cerebrospinal fluid demonstrated an inflammatory response. Growth ofC. immitiswas demonstrated by quantitative fungal culture from brains and proximal spinal cords.