Consistent Condom Use Reduces the Genital Human Papillomavirus Burden Among High-Risk Men: The HPV Infection in Men Study
Consistent Condom Use Reduces the Genital Human Papillomavirus Burden Among High-Risk Men: The HPV Infection in Men Study
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DOI：
10.1093/infdis/jit191
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发表时间：
2013-08-01
影响因子：
6.4
通讯作者：
Giuliano, Anna R.
中科院分区：
文献类型：
--
作者：
Campbell, Christine M. Pierce;Lin, Hui-Yi;Giuliano, Anna R.
背景。支持避孕套对男性人乳头瘤病毒（HPV）感染有效性的数据有限。因此，我们研究了持续使用避孕套对生殖器HPV感染和感染持续时间的影响。一项前瞻性分析在男性HPV感染研究中进行，这是一项跨国HPV队列研究。最近性生活活跃的男性（n = 3323）根据性风险行为和伴侣关系进行分层。使用Cox比例风险回归，对每个风险组的HPV感染和清除率的类型特异性发生率进行建模，以评估与避孕套使用的独立关联。在调整了国家、年龄、种族、受教育时间、吸烟、饮酒和最近性伴侣的数量后，无稳定性伴侣且始终使用避孕套的男性感染HPV的风险比从不使用避孕套的男性低2倍（风险比，0.54）。在调整了国家、年龄、种族、教育持续时间、婚姻状况、吸烟、饮酒和最近的性伴侣数量后，与从不使用避孕套的男性相比，非一夫一妻制男性与不稳定的性伴侣总是使用避孕套的男性清除致癌HPV感染的概率高30%（风险比，1.29）。在一夫一妻制的男性中，没有观察到使用避孕套的保护作用。应在接种HPV疫苗的同时推广避孕套，以预防男性感染HPV。
Background. Data supporting the efficacy of condoms against human papillomavirus (HPV) infection in males are limited. Therefore, we examined the effect of consistent condom use on genital HPV acquisition and duration of infection.Methods. A prospective analysis was conducted within the HPV Infection in Men Study, a multinational HPV cohort study. Men who were recently sexually active (n = 3323) were stratified on the basis of sexual risk behaviors and partnerships. Using Cox proportional hazards regression, type-specific incidence of HPV infection and clearance were modeled for each risk group to assess independent associations with condom use.Results. The risk of HPV acquisition was 2-fold lower among men with no steady sex partner who always used condoms, compared with those who never used condoms (hazard ratio, 0.54), after adjustment for country, age, race, education duration, smoking, alcohol, and number of recent sex partners. The probability of clearing an oncogenic HPV infection was 30% higher among nonmonogamous men who always used condoms with nonsteady sex partners, compared with men who never used condoms (hazard ratio, 1.29), after adjustment for country, age, race, education duration, marital status, smoking, alcohol, and number of recent sex partners. No protective effects of condom use were observed among monogamous men.Conclusions. Condoms should be promoted in combination with HPV vaccination to prevent HPV infection in men.