Intercellular adhesion molecule 1-dependent activation of interleukin 8 expression in Candida albicans-infected human gingival epithelial cells
Intercellular adhesion molecule 1-dependent activation of interleukin 8 expression in Candida albicans-infected human gingival epithelial cells
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DOI：
10.1128/iai.73.1.622-626.2005
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发表时间：
2005-01-01
影响因子：
3.1
通讯作者：
Hamada, T
中科院分区：
文献类型：
--
作者：
Egusa, H;Nikawa, H;Hamada, T
口腔黏膜上皮细胞对白细胞介素8（IL-8）和细胞间粘附分子1（ICAM-1）的诱导表达增加可能在口咽念珠菌病的宿主防御机制中发挥作用;然而，关于白念珠菌感染过程中这些分子在人牙龈上皮细胞（HGECs）上的表达特征知之甚少。在这份报告中，我们提出的证据表明，中和抗体抗ICAM-1抑制粘附的C。白念珠菌感染HGECs和白念珠菌诱导的IL-8的产生，提示ICAM-1在HGECs识别和信号传导中的作用，以表达IL-8。白色念珠菌。
Increased induction of interleukin 8 (IL-8) and intercellular adhesion molecule 1 (ICAM-1) by oral epithelial cells may play a role in the host defense mechanism in oropharyngeal candidiasis; however, little is known about the expression feature of these molecules on human gingival epithelial cells (HGECs) during Candida albicans infection. In this report we present evidence that neutralization with antibody against ICAM-1 inhibited both the adherence of C. albicans to HGECs and the Candida-induced production of IL-8, suggesting a role for ICAM-1 in recognition and signaling in HGECs to express IL-8 upon infection with C. albicans.