Paternal age and preterm birth in Italy, 1990 to 1998
Paternal age and preterm birth in Italy, 1990 to 1998
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DOI：
10.1097/01.ede.0000197053.61176.f4
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发表时间：
2006-03-01
期刊：
影响因子：
5.4
通讯作者：
Zonta, LA
中科院分区：
文献类型：
--
作者：
Astolfi, P;De Pasquale, A;Zonta, LA
背景：据报道，父亲年龄过大会影响妊娠结局。在这里，我们通过使用一个非常大的国家数据集调查了父亲年龄大与早产的关系。方法：我们分析1990 - 1998年意大利20-24岁和25-29岁母亲的首胎单胎数据（n = 1,510,823）。在调整混杂因素后，通过logistic回归模型评估父亲年龄类别（20-24岁、25-29岁、30-34岁、35-39岁、40-44岁、45-49岁、50+岁）的总体早产（< 37周妊娠）、重度早产（< 32周）和中度早产（32-36周）的优势比。采用非参数回归模型拟合父亲年龄对极早产发生率的影响。结果：优势比随着父亲年龄的增加，重度早产比中度早产增加得更快；在45岁至49岁的父亲中，20岁至24岁和25岁至29岁的母亲中，极早产的比值比分别达到1.91（95%可信区间= 1.08-3.38）和1.72（1.25-2.36）。结论：本研究证实，父亲年龄与早产风险有关。这种影响在重度早产中更为明显，但对中度早产也有影响。
Background: Advanced paternal age has been reported to impair pregnancy outcome. Here, we investigated the association of advanced paternal age with preterm birth by using a very large national data set.Methods: We analyzed data from 1990 to 1998 on Italian firstborn singletons to mothers 20-24 and 25-29 years of age (n = 1,510,823). Odds ratios for overall preterm (< 37 weeks' gestation) , very preterm (< 32 weeks), and moderate preterm (32-36 weeks) births were evaluated through logistic regression models in paternal age classes (20-24, 25-29, 30-34, 35-39, 40-44, 45-49, 50+ years) after adjustment for confounders. Nonparametric regression models were used to fit the effect of paternal ageing on the incidence of very preterm births.Results: Odds ratios increased with paternal age more rapidly for very preterm than for moderate preterm births; among 45- to 49-year-old fathers, odds ratios for very preterm births reached 1.91 (95% confidence interval = 1.08-3.38) and 1.72 (1.25-2.36), respectively, in 20- to 24- and 25- to 29-year-old mothers.Conclusions: This study confirms that paternal age contributes to the risk of preterm birth. The effect is stronger on very preterm births but also influences moderate preterm births.