Bronchoscopic phototherapy with hematoporphyrin derivative for treatment of localized bronchogenic carcinoma: a 5-year experience.
Bronchoscopic phototherapy with hematoporphyrin derivative for treatment of localized bronchogenic carcinoma: a 5-year experience.
复制标题
血卟啉衍生物支气管镜光疗治疗局限性支气管癌：5 年经验。
DOI：
10.1016/s0025-6196(12)61520-1
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发表时间：
1987
影响因子：
8.9
通讯作者：
Cortese,DA
中科院分区：
文献类型：
--
作者：
Edell,ES;Cortese,DA
1980年12月至1986年4月，在我们的机构，38例癌症患者，涉及气管支气管树（共40个癌）完成了至少一个疗程的血卟啉衍生物光疗。13例患者（14例癌）完全缓解。这些癌症中有11例在3至53个月的随访期间没有复发。3例癌分别在9、12和35个月时复发。对于26个癌，反应是不完全的，替代治疗是必要的。完全缓解患者的癌在放射学上是隐匿性的，表面积小于3 cm 2，在支气管镜检查时表现为浅表性。我们的经验支持使用血卟啉衍生物光疗作为一种替代手术切除精心挑选的患者。
Between December 1980 and April 1986 at our institution, 38 patients with cancer that involved the tracheobronchial tree (a total of 40 carcinomas) completed at least one course of hematoporphyrin derivative phototherapy. A complete response occurred in 13 patients (with 14 carcinomas). Eleven of these carcinomas did not recur during follow-up periods that ranged from 3 to 53 months. Three carcinomas recurred at 9, 12, and 35 months, respectively. For 26 carcinomas, the response was less than complete, and alternative therapy was necessary. The carcinomas in patients with a complete response were radiographically occult, were less than 3 cm2in surface area, and appeared superficial at bronchoscopy. Our experience supports the use of hematoporphyrin derivative phototherapy as an alternative to surgical resection in carefully selected patients.