HLA-DR EXPRESSION BY LABIAL MINOR SALIVARY-GLAND TISSUES IN SJOGRENS-SYNDROME
HLA-DR EXPRESSION BY LABIAL MINOR SALIVARY-GLAND TISSUES IN SJOGRENS-SYNDROME
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DOI：
10.1136/ard.45.8.677
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发表时间：
1986-08-01
影响因子：
27.4
通讯作者：
DETRICK, B
中科院分区：
文献类型：
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作者：
MOUTSOPOULOS, HM;HOOKS, JJ;DETRICK, B
应用生物素-亲和素-免疫过氧化物酶四步法检测了原发性和继发性干燥综合征患者和正常对照组的小涎腺活检标本。原发性和继发性干燥综合征患者的浸润细胞组成相似，主要由T淋巴细胞组成，以T辅助/诱导细胞为主。B淋巴细胞（Leu-14）约占浸润淋巴细胞的20-35%，而仅观察到少数OKM 1（单核细胞/巨噬细胞）细胞和Leu-7+（自然杀伤细胞; NK）细胞。大部分浸润淋巴细胞表达HLA-DR抗原。在对照组的活检标本中，没有浸润;然而，散在的淋巴细胞也主要是T淋巴细胞。最后，腺上皮细胞（导管和腺泡）不适当地表达HLA-DR抗原，与对照组相比，发现最小的HLA-DR表达。
Minor salivary gland biopsy specimens from patients with Sjogern''s syndrome (primary and secondary) and from normal controls were examined with the four step biotin-avidin-immunoperoxidase assay. The composition of the infiltrating cells was similar in patients with both primary and secondary Sjogren''s syndrome, consisting primarily of T lymphocytes with predominance of T helper/inducer cells. B lymphocytes (Leu-14) were approximately 20-35% of the infiltrating lymphocytes, while only a few OKM1 (monocytes/macrophages) cells and Leu-7+ (natural killer; NK) cells were observed. The majority of infiltrating lymphocytes expressed HLA-DR antigens. In the biopsy specimens of the controls there were no infiltrates; the scattered lymphocytes, however, were also predominantly T lymphocytes. Finally, the glandular epithelial cells (ducts and acini) were inappropriately expressing HLA-DR antigens, in contrast with controls where minimal HLA-DR expression was found.