A role for testosterone in the maintenance of seasonally appropriate body mass but not in lipectomy-induced body fat compensation in Siberian hamsters.
A role for testosterone in the maintenance of seasonally appropriate body mass but not in lipectomy-induced body fat compensation in Siberian hamsters.
复制标题
睾酮在维持季节性适当体重方面发挥作用，但在西伯利亚仓鼠脂肪切除术引起的身体脂肪补偿中没有作用。
DOI：
10.1002/j.1550-8528.1995.tb00118.x
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Bartness,TJ
中科院分区：
文献类型：
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作者：
Mauer,MM;Bartness,TJ
本研究的目的是测试生殖活跃的长日饲养西伯利亚仓鼠的血清睾酮(T)浓度是否对去除附睾白色脂肪组织（EWAT）后未切除脂肪垫的代偿性增加和/或维持这些仓鼠的季节性适当体重是必要的。长时间饲养的仓鼠被阉割或保持完整，假性或EWAT切除脂肪，并给予T或胆固醇(C)植入物。除了两组阉割的经T处理的大鼠被配对喂食给经C处理的大鼠，以控制T对食物摄取量的影响外，所有组都可以自由取食。与所有其他组相比，经C处理的阉割猫体重下降，这表明T在维持季节性适当体重方面的作用。由于接受T治疗的仓鼠与这些缺乏T的仓鼠配对喂养，表现出季节性适当的体重和脂肪垫质量，因此T似乎不会通过调节食物摄入量来影响这些参数。C处理动物的所有脂肪垫都小于随意喂养或配对喂养、T处理的去势动物；然而，在C处理的假性去脂组中，EWAT是唯一比性腺完整的假性去脂组小的脂肪垫。这一结果可能表明EWAT对T的敏感性增强。T对脂肪垫质量的影响与脂蛋白脂肪酶活性的比例变化无关，这表明T对该物种脂肪积累的主要影响是通过其他机制发生的。经C‐处理的去脂仓鼠在去脂后8周通过腹膜后和腹股沟WAT肿块的无统计学意义的增加来补偿体脂不足。这一发现表明，虽然T对于维持季节性适宜的体重是必要的，但对于EWAT脂肪切除术后的脂肪垫补偿却不是必要的。
The purpose of this study was to test whether serum testosterone (T) concentrations characteristic of reproductively active, long‐day‐housed Siberian hamsters are necessary for compensatory increases in nonexcised fat pads following removal of epididy‐mal white adipose tissue (EWAT) and/or for the maintenance of seasonally appropriate body weights in these hamsters. Long‐day‐housed hamsters were castrated or left intact, sham or EWAT lipectomized, and given T or cholesterol (C) implants. All groups had ad libitum food access except for two castrated T‐treated groups that were pair‐fed to their C‐treat‐ed counterparts to control for effects of T on food intake. C‐treated castrates had decreased body weights compared with all other groups, suggesting a role of T in the maintenance of seasonally appropriate body mass. Since the T‐treated hamsters pair‐fed to these T‐deficient animals exhibited seasonally appropriate body weights and fat pad masses, T does not appear to affect these parameters through the modulation of food intake. All fat pads of C‐treated animals were smaller than those of ad libitum‐ or pair‐fed, T‐treated castrates; however, EWAT was the only fat pad that was smaller in the C‐treated sham‐lipectomized group than in gonad‐intact sham‐lipectomized hamsters. This result may indicate an enhanced sensitivity of EWAT to T. The effects of T on fat pad mass were not associated with proportionate changes in lipoprotein lipase activity, suggesting that the major effect of T on fat accumulation occurs through other mechanisms in this species. C‐treated lipectomized hamsters compensated for the body fat deficit 8 weeks after lipectomy via statistically nonsignificant increases in retroperitoneal and inguinal WAT mass. This finding suggests that, whereas T is necessary for maintenance of seasonally‐appropriate body weight, it is not necessary for fat pad compensation after EWAT lipectomy.