Data on rotary die filling performance of various pharmaceutical powders.
Data on rotary die filling performance of various pharmaceutical powders.
复制标题
各种药粉的旋转模头灌装性能数据。
DOI：
10.1016/j.dib.2020.106220
复制
发表时间：
2020
期刊：
影响因子：
1.2
通讯作者：
Tang X
中科院分区：
文献类型：
--
作者：
Tang X
旋转模头充填作为药品压片的关键工艺步骤之一，目前还没有得到很好的理解。为了解决这个问题，开发了一种带有桨式给料机的旋转模头填充系统模型，以密切模拟工业过程。使用该模型系统，在不同的转台和桨速度的各种药物粉末的性能进行了评价，并检查了工艺条件和材料性能的填充变化的依赖性。创建并报告了一个综合数据集，以显示材料和工艺参数对模具填充性能和填充一致性的影响。据信，这些数据还可用于数据驱动的过程建模和开发用于制药的强大机器学习模型。
As one of critical process steps during pharmaceutical tabletting, rotary die filling is still not well understood. To address this issue, a model rotary die filling system with a paddle feeder was developed to closely mimic the industrial process. Using this model system, the performance of various pharmaceutical powders at different turret and paddle speeds was evaluated, and the dependence of fill variation on process conditions and material properties was examined. A comprehensive dataset was created and reported here to show the effects of material and process parameters on the die filling performance and the filling consistency. It is believed that the data can also be used for data-driven process modelling and for developing robust machine learning models for pharmaceutical manufacturing.