No changes in rat benzodiazepine receptors after withdrawal from continuous treatment with lorazepam and diazepam.
No changes in rat benzodiazepine receptors after withdrawal from continuous treatment with lorazepam and diazepam.
复制标题
劳拉西泮和地西泮连续治疗停药后，大鼠苯二氮卓受体没有变化。
DOI：
10.1016/0024-3205(79)90330-8
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发表时间：
1979
期刊：
影响因子：
6.1
通讯作者：
R. Squires
中科院分区：
文献类型：
--
作者：
C. Braestrup;M. Nielsen;R. Squires
停用地西潘90 mg/kg/d或劳拉西潘60 mg/kg/d治疗8周后，停药5天和11天后，大鼠前脑膜0℃时苯二氮受体的数量和对~H-地西潘的体外亲和力没有一致的变化。从出生前10天到出生后7天的每日暴露对苯二氮卓类受体也没有明显影响。因此，禁欲和对苯二氮卓类药物的耐受性与脑部苯二氮卓类受体的变化无关。
Five and 11 days after withdrawal from 8 weeks of treatment with 90 mg/kg/day of diazepam po or 60 mg/kg/day of lorazepam po there were no consistent changes in the number of benzodiazepine receptors or apparent affinity in vitro for 3 H-diazepam at 0° C in rat forebrain membranes. Daily exposure of rats from 10 days before birth until 7 days after birth was also without gross effects on the benzodiazepine receptor. Abstinence and tolerance to benzodiazepines were thus not attributable to changes in brain benzodiazepine receptors.