WEIGHT-LOSS REDUCES ABDOMINAL FAT AND IMPROVES INSULIN ACTION IN MIDDLE-AGED AND OLDER MEN WITH IMPAIRED GLUCOSE-TOLERANCE
WEIGHT-LOSS REDUCES ABDOMINAL FAT AND IMPROVES INSULIN ACTION IN MIDDLE-AGED AND OLDER MEN WITH IMPAIRED GLUCOSE-TOLERANCE
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DOI：
10.1016/0026-0495(95)90153-1
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发表时间：
1995-11-01
影响因子：
9.8
通讯作者：
GOLDBERG, AP
中科院分区：
文献类型：
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作者：
COLMAN, E;KATZEL, LI;GOLDBERG, AP
衰老与腹部脂肪堆积增加、葡萄糖耐受不良和胰岛素抵抗有关。我们对一组糖耐量正常或受损的肥胖中老年男性进行了假设，即饮食引起的体重减轻会减少腹部脂肪分布，改善葡萄糖耐量和胰岛素作用。35名男性（平均年龄60 +/- 8岁）在基线和饮食诱导体重减轻9个月后进行口服葡萄糖耐量试验（OGITs）。15名没有参加减肥干预的年龄和肥胖程度相当的男性作为对照组。受试者体重减轻9.0 +/- 2.0 kg（平均+/- SD）
Aging is associated with an increased accumulation of abdominal fat, glucose intolerance, and insulin resistance. We tested the hypothesis that diet-induced weight loss would reduce the abdominal distribution of fat and improve glucose tolerance and insulin action in a group of obese middle-aged and older men with normal or impaired glucose tolerance (IGT). Oral glucose tolerance tests (OGITs) were performed at baseline and after 9 months of diet-induced weight loss in 35 men (mean age, 60 +/- 8 years). Fifteen men of comparable age and degree of obesity who did not participate in the weight loss intervention served as controls. Subjects lost 9.0 +/- 2.0 kg (mean +/- SD) body weight (P