State-of-the-art management of locally advanced head and neck cancer.
State-of-the-art management of locally advanced head and neck cancer.
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DOI：
10.1038/sj.bjc.6602510
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发表时间：
2005-04-25
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
在过去的20年中，头颈部鳞状细胞癌（HNSCC）的治疗方法发生了巨大变化，主要是由于新方法的出现，如综合治疗以及手术和放射治疗技术的改进。特别是局部晚期疾病，其复发率和死亡率非常高，现在在大多数情况下与长期无病生存有关。本文将重点介绍局部晚期HNSCC，这往往仍然是一个临床挑战，审查国家的最先进的治疗，并介绍有前途的新疗法。该领域继续快速发展，过去一年的新证据清楚地证明了辅助化疗（CRT）的益处，以及早期证据显示使用表皮生长因子受体抑制剂与放疗联合使用可提高生存率。对于局部晚期疾病的患者，有各种不同的治疗方案，但同时，当试图选择最合适的方案时，众多的选择可能会困扰临床医生。本文将尝试把各种方法的角度，并提出一个循证治疗算法。
During the past 20 years, treatments for head and neck squamous cell carcinoma (HNSCC) have changed dramatically owing largely to the advent of novel approaches such as combined modality therapy as well as improvements in surgical and radiotherapeutic techniques. Locally advanced disease in particular, which engendered very high recurrence and mortality rates, is now associated with long-term disease-free survival in the majority of cases. This article will focus on locally advanced HNSCC, which frequently remains a clinical challenge, review state-of-the-art therapy, and introduce promising novel therapies. The field continues to evolve rapidly with new evidence during the past year clearly establishing the benefit of adjuvant chemoradiotherapy (CRT), as well as early evidence showing improved survival with the use of an epidermal growth factor receptor inhibitor in combination with radiotherapy. There are varied regimens in use for patients with locally advanced disease, but at the same time the multitude of options can plague the clinician when trying to select the most appropriate one. This article will attempt to put the various approaches into perspective and propose an evidence-based treatment algorithm.
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影响因子：
45.3
作者：
Adelstein, DJ;Saxton, JP;Carroll, MA
通讯作者：
Carroll, MA
DOI：
10.1002/hed.10394
发表时间：
2004-05-01
影响因子：
2.9
作者：
Argiris, A;Stenson, KM;Vokes, EE
通讯作者：
Vokes, EE
影响因子：
2.2
作者：
Hainsworth, JD;Meluch, AA;Greco, FA
通讯作者：
Greco, FA
DOI：
10.1016/0360-3016(92)90646-y
发表时间：
1992-01-01
影响因子：
7
作者：
HUANG, DT;JOHNSON, CR;GRIMES, M
通讯作者：
GRIMES, M
影响因子：
158.5
作者：
Brizel, DM;Albers, ME;Prosnitz, LR
通讯作者：
Prosnitz, LR