Retinal nerve fibre layer thickness in full-term children assessed with Heidelberg retinal tomography and optical coherence tomography: normal values and interocular asymmetry
Retinal nerve fibre layer thickness in full-term children assessed with Heidelberg retinal tomography and optical coherence tomography: normal values and interocular asymmetry
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DOI：
10.1111/j.1755-3768.2009.01680.x
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发表时间：
2011-03-01
影响因子：
3.4
通讯作者：
Alm, Albert
中科院分区：
文献类型：
--
作者：
Larsson, Eva;Eriksson, Urban;Alm, Albert
目的：本研究旨在探讨正常值和视网膜神经纤维层（RNFL）厚度的眼间差异，使用光学相干断层扫描（OCT）和海德堡视网膜断层扫描（HRT），在5-16岁的足月出生的正常birthweights.Methods：五十六名儿童正常视力和屈光度进行了检查，与Stratus OCT和HRT。对每只眼睛进行三次检查。每名儿童的一只眼睛被随机分配用于正常值分析。对54只眼的结果进行了评价。计算RNFL厚度的平均值。计算变异系数和组内相关系数。左右眼之间的相关性和差异的限制，确定为两种methods.Results：平均RNFL厚度为98.4 μ m（标准差[SD] 7.88 μ m）评估与OCT和213.0 μ m（SD 54.0 μ m）与HRT评估。OCT和HRT的变异系数分别为2.9%和5.6%，组内相关系数分别为0.85和0.88。两个眼睛之间的差异范围从-9 μ m到9 μ m的OCT和从-109 μ m到87 μ mHRT.Conclusions：OCT和HRT都可以用于5-16岁的儿童，但OCT提供的RNFL厚度的测定，无论是在同一只眼睛的重复检查，并在两个眼睛之间的比较较少的变化。本研究提供了健康儿童的正常RNFL厚度值，可用于与视神经疾病儿童的值进行比较。
Purpose: This study aimed to investigate normal values and interocular differences in retinal nerve fibre layer (RNFL) thickness, using optical coherence tomography (OCT) and Heidelberg retinal tomography (HRT), in 5-16-year-old children born at full-term with normal birthweights.Methods: Fifty-six children with normal visual acuity and refraction were examined with Stratus OCT and HRT. Three examinations were performed in each eye. One eye in each child was randomized for analyses of normal values. Findings in 54 eyes were evaluated. Mean values of RNFL thickness were calculated. Coefficients of variance and intraclass correlations were calculated. The correlation between right and left eyes and the limits of difference were determined for both methods.Results: Mean RNFL thickness was 98.4 mu m (standard deviation [SD] 7.88 mu m) assessed with OCT and 213.0 mu m (SD 54.0 mu m) assessed with HRT. No correlations between age or gender and RNFL thickness were found. The coefficients of variance were 2.9% and 5.6% for OCT and HRT, respectively, and intraclass correlations were 0.85 and 0.88, respectively. The limits of difference between the two eyes ranged from -9 mu m to 9 mu m with OCT and from -109 mu m to 87 mu m with HRT.Conclusions: Both OCT and HRT can be used in children aged 5-16 years, but OCT provides less variability in determinations of RNFL thickness, both in repeated examinations of the same eye and in comparisons between the two eyes. The present study provides values for normal RNFL thickness in healthy children which can be used to make comparisons with values in children with optic nerve diseases.