Human chorionic gonadotropin treatment: a viable option for management of secondary hypogonadism and male infertility.
Human chorionic gonadotropin treatment: a viable option for management of secondary hypogonadism and male infertility.
复制标题
人绒毛膜促性腺激素治疗：治疗继发性性腺功能减退症和男性不育症的可行选择。
DOI：
10.1080/17446651.2021.1863783
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发表时间：
2021
影响因子：
3.2
通讯作者：
Takahiro Maekawae & Shigeo Horie
中科院分区：
文献类型：
--
作者：
Julius Fink;Brad J. Schoenfeld;Anthony C. Hackney;Takahiro Maekawae & Shigeo Horie
导语：睾丸素水平低下及其症状是影响许多男性的一种疾病，对健康有严重影响。睾酮影响新陈代谢、骨骼、关节和韧带、心血管系统、肝脏、性功能、肌肉质量和神经系统。如今，由于最近的研究表明睾丸激素替代疗法的好处，这种疗法在老年男性中越来越受欢迎。然而，替代睾丸素会增加不育的风险。报道内容：人绒毛膜促性腺激素(HCG)被用于治疗男性不育，因为它具有促黄体生成素(LH)样作用，可以触发睾酮和精子的产生。由于这些对睾酮产生的积极作用，人绒毛膜促性腺激素也被用于治疗继发性性腺功能减退症。在这篇综述中，基于Google Scholar网站1977-2020年的文献综述，我们总结了目前关于HCG治疗低睾酮患者的研究，并概述了HCG治疗继发性性腺功能减退与睾酮替代疗法的利弊。专家观点：HCG触发睾酮和精子产生的作用，而不会出现睾酮替代疗法中看到的对生育的副作用，使HCG疗法成为继发性性腺功能减退患者的首选治疗方案。
Introduction: Low testosterone and its symptoms is a condition affecting many males with severe repercussions on health. Testosterone affects metabolism, bones, joints, and ligaments, the cardiovascular system, liver, sexual functions, muscle mass, and the nervous system. Nowadays, due to recent research showing the benefits of testosterone replacement therapy, this treatment is gaining in popularity among aging men. However, testosterone replacement can increase the risk of infertility.Areas covered: Human chorionic gonadotropin (HCG) is used in the treatment of male infertility due to its luteinizing hormone (LH)-like action triggering testosterone and sperm production. Due to these positive effects on testosterone production, HCG has also been used to treat secondary hypogonadism. In this review, based on a literature review for the years 1977–2020 via Google Scholar, we summarize the current research on HCG as treatment for patients suffering from low testosterone and provide an overview of the pros and contras for HCG therapy as compared to testosterone replacement therapy for the treatment of secondary hypogonadism.Expert opinion: The testosterone and sperm production triggering effects of HCG without the side effects on fertility seen in testosterone replacement therapy make HCG therapy a prime candidate for patients suffering from secondary hypogonadism.