Influence of integration of TiO2 nanorods into its nanodot films on pre-osteoblast cell responses
Influence of integration of TiO2 nanorods into its nanodot films on pre-osteoblast cell responses
复制标题
TiO2 纳米棒整合到其纳米点薄膜中对前成骨细胞反应的影响。
DOI：
10.1016/j.colsurfb.2014.12.002
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发表时间：
2015-02-01
影响因子：
5.8
通讯作者：
Wang, Huiming
中科院分区：
文献类型：
--
作者：
Cheng, Kui;Yu, Mengfei;Wang, Huiming
设计具有合适纳米结构的种植体表面被认为是促进成骨细胞生长和骨整合的有效途径。在本工作中，通过水热生长将纳米棒集成到纳米点膜中，形成由两个纳米结构元素组成的纳米结构表面。薄膜的表面微结构与薄膜的整合度有关。低集成度导致两个纳米结构元素暴露的表面纳米结构，而高集成度导致表面类似于纳米棒薄膜。纳米棒的整合对成骨前细胞的反应有明显影响，促进了细胞的成骨。整合的纳米结构元素和改变的表面拓扑结构中的两个因素被认为是增强细胞反应的原因。前者被认为发挥了更重要的作用，因为纳米棒倾向于优先吸附人纤维连接蛋白，从而更早地开始分化为成骨。我们预计这项工作可能有助于深入了解纳米结构表面与细胞之间的相互作用。(C)2014爱思唯尔B.V.保留所有权利。
Design of an implant surface with appropriate nanostructures has been considered to be an effective way to promote osteoblast cell growth and osseointegration. In this work, TiO2 nanorods were integrated into TiO2 nanodot films by hydrothermal growth to engineer a nanostructured surface composed of two nano-structural elements. The surface microstructure of the films depended on the integration degree. Low integration led to a surface nanostructure with exposure of the two nano-structural elements, and high integration resulted in a similar surface to a nanorod film. The nanorod integration had an obvious influence on pre-osteoblast cell responses and accelerated the cellular osteogenesis. Two factors of the integrated nano-structural element and the changed surface topology are believed to be responsible for enhancing cellular responses. The former is considered to play a more significant role because the nanorods tended to adsorb human fibronectin preferentially so as to begin differentiation to osteogenesis earlier. We anticipate this work may assist to gain insight into understanding of the interactions between nanostructured surfaces with cells. (C) 2014 Elsevier B.V. All rights reserved.