Interplay between bone marrow and liver in the pathogenesis of hepatic fibrosis.
Interplay between bone marrow and liver in the pathogenesis of hepatic fibrosis.
复制标题
骨髓与肝脏在肝纤维化发病机制中的相互作用。
DOI：
10.1111/j.1872-034x.2012.00978.x
复制
发表时间：
2012
期刊：
影响因子：
4.2
通讯作者：
Yutaka Inagaki
中科院分区：
文献类型：
--
作者：
Inagaki Y;Higashiyama R;and Higashi K.;Yutaka Inagaki
分子生物学和再生医学技术的最新进展使得识别骨髓（BM）来源的细胞迁移到包括肝脏在内的各种纤维化器官成为可能。许多研究报道，迁移到纤维化肝组织中的骨髓来源的细胞表现出肌成纤维细胞样表型，可能参与肝纤维化的进展。另一方面，也有研究表明，骨髓来源的细胞表达基质金属蛋白酶，有助于实验性肝纤维化的消退。这些矛盾的结果可能至少部分源于这些研究中使用的各种不同方法的不确定性。在这篇综述文章中，我们描述了骨髓和肝脏在肝纤维化进展和消退中的相互作用，强调需要具有高特异性和敏感性的合格方法来评估骨髓来源的细胞在胶原蛋白生成中的作用。
Recent advances in the technologies of both molecular biology and regenerative medicine have made it possible to identify bone marrow (BM)‐derived cells migrating into various fibrotic organs including the liver. A number of studies have reported that BM‐derived cells migrating into fibrotic liver tissue exhibit a myofibroblast‐like phenotype and may participate in the progression of liver fibrosis. On the other hand, it has also been shown that BM‐derived cells express matrix metalloproteinases and contribute to the regression of experimental liver fibrosis. These contradictory results may arise, at least in part, from the uncertainty of various different methods that have been used in those studies. In this review article, we describe the interplay between BM and liver in the progression and regression of liver fibrosis, with an emphasis on the necessity of qualified methods with high specificity and sensitivity to evaluate the role of BM‐derived cells in collagen production.