A pilot study of indocyanine green videoangiography-guided laser photocoagulation of occult choroidal neovascularization in age-related macular degeneration.
A pilot study of indocyanine green videoangiography-guided laser photocoagulation of occult choroidal neovascularization in age-related macular degeneration.
复制标题
吲哚菁绿视频血管造影引导激光光凝治疗年龄相关性黄斑变性隐匿性脉络膜新生血管的初步研究。
DOI：
10.1001/archopht.1994.01090160041020
复制
发表时间：
1994
影响因子：
--
通讯作者：
D. Orlock
中科院分区：
文献类型：
--
作者：
J. Slakter;L. Yannuzzi;J. Sorenson;D. Guyer;A. Ho;D. Orlock
目的
评价数字吲哚菁绿色视频血管造影术在年龄相关性黄斑变性“隐匿性”脉络膜新生血管临床和荧光素血管造影证据患者中的应用，并研究吲哚菁绿色视频血管造影术引导的激光光凝术作为治疗方法。
方法
采用吲哚菁绿色视频血管造影研究了347例渗出性年龄相关性黄斑变性和隐匿性脉络膜新生血管的症状和临床表现。当吲哚菁绿色视频血管造影显示出轮廓清晰的高荧光区域（推测为脉络膜新生血管的病灶区域）时，使用常规指南选择患者进行激光治疗。
结果
发现347只眼中有79只（23%）存在局部和可定义的病变，可能适合激光光凝治疗;这79只治疗眼中有44只（56%）的渗出性表现完全消退。79只眼中10只眼（13%）视力提高，42只眼（53%）视力稳定。
结论
吲哚菁绿色血管造影引导下的激光光凝治疗对少数继发于年龄相关性黄斑变性的隐匿性脉络膜新生血管患者的解剖学和视力改善有希望。这项试点研究需要进一步研究，以调查这种治疗形式的有效性和安全性。
PURPOSE
To evaluate the use of digital indocyanine green videoangiography in patients with clinical and fluorescein angiographic evidence of "occult" choroidal neovascularization in age-related macular degeneration and to investigate indocyanine green videoangiography-guided laser photocoagulation as a therapeutic approach.
METHODS
Three hundred forty-seven consecutive patients with exudative age-related macular degeneration and symptoms and clinical manifestations of occult choroidal neovascularization were studied with indocyanine green videoangiography. Patients were selected for laser treatment, using conventional guidelines, when indocyanine green videoangiography demonstrated a well-delineated area of hyperfluorescence, presumed to be a focal area of choroidal neovascularization.
RESULTS
Seventy-nine (23%) of 347 eyes were found to have a localized and definable lesion that was potentially amenable to laser photocoagulation therapy; 44 (56%) of these 79 treated eyes had complete resolution of their exudative manifestations. Visual acuity improvement was noted in 10 (13%) of 79 eyes, and stabilization of vision achieved in 42 eyes (53%).
CONCLUSION
Laser photocoagulation treatment guided by indocyanine green videoangiography was shown to produce promising anatomical and visual improvement in a small number of patients with occult choroidal neovascularization secondary to age-related macular degeneration. This pilot study warrants further research to investigate the efficacy and safety of this form of treatment.
脉络膜新生血管的吲哚菁绿视频血管造影。
影响因子：
13.7
作者：
Destro,M;Puliafito,CA
通讯作者：
Puliafito,CA
影响因子：
13.7
作者：
D. Guyer;C. Puliafito;J. Monés;E. Friedman;Warren J. Chang;S. Verdooner
通讯作者：
D. Guyer;C. Puliafito;J. Monés;E. Friedman;Warren J. Chang;S. Verdooner
影响因子：
--
作者：
T. Meredith;P. Sternberg;J. M. Brown;R. Murphy;S. Fine;A. Schachat;M. Elman;N. Bressler;J. Haller;P. Orr;J. Starr;K. MacMillan;L. Singerman;T. Rice;M. Novak;S. Smith-Brewer;D. Preseren;G. Fish;B. Jost
通讯作者：
T. Meredith;P. Sternberg;J. M. Brown;R. Murphy;S. Fine;A. Schachat;M. Elman;N. Bressler;J. Haller;P. Orr;J. Starr;K. MacMillan;L. Singerman;T. Rice;M. Novak;S. Smith-Brewer;D. Preseren;G. Fish;B. Jost