A pathway in primate brain for internal monitoring of movements
A pathway in primate brain for internal monitoring of movements
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DOI：
10.1126/science.1069590
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发表时间：
2002-05-24
期刊：
影响因子：
56.9
通讯作者：
Wurtz, RH
中科院分区：
文献类型：
--
作者：
Sommer, MA;Wurtz, RH
跟踪我们所做的动作是至关重要的，其中一种方法是监测神经元运动命令的相关性或必然放电。我们假设，以前确定的通路从脑干到额叶皮质可能携带必然的放电信号。我们发现，在这条通路中的神经元活动编码即将到来的眼球运动和失活的途径损害连续的眼球运动与损失的必然放电，而不影响单个眼球运动。这些结果确定了灵长类动物猕猴大脑中传递必然放电信号的通路。
It is essential to keep track of the movements we make, and one way to do that is to monitor correlates, or corollary discharges, of neuronal movement commands. We hypothesized that a previously identified pathway from brainstem to frontal cortex might carry corollary discharge signals. We found that neuronal activity in this pathway encodes upcoming eye movements and that inactivating the pathway impairs sequential eye movements consistent with loss of corollary discharge without affecting single eye movements. These results identify a pathway in the brain of the primate Macaca mulatta that conveys corollary discharge signals.