Kurahyne, an acetylene-containing lipopeptide from a marine cyanobacterial assemblage of Lyngbya sp.
Kurahyne, an acetylene-containing lipopeptide from a marine cyanobacterial assemblage of Lyngbya sp.
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DOI：
10.1039/c4ra00132j
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发表时间：
2014-01-01
期刊：
影响因子：
3.9
通讯作者：
Suenaga, Kiyotake
中科院分区：
文献类型：
--
作者：
Iwasaki, Arihiro;Ohno, Osamu;Suenaga, Kiyotake
Kurahyne是一种新的含乙炔的脂肽，从一种主要由鞘丝藻（Lyngbya sp.）组成的蓝藻组合中分离得到，其结构通过光谱分析和水解产物的手性HPLC分析进行了鉴定。Kurahyne对人癌细胞生长有抑制作用，对HeLa细胞有诱导凋亡作用，且可能定位于线粒体。
Kurahyne, a new acetylene-containing lipopeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Kurahyne inhibited the growth of human cancer cells and induced apoptosis in HeLa cells, and it seemed to localize in mitochondria.