Expression of ERBB Family Members as Predictive Markers of Prostate Cancer Progression and Mortality.
Expression of ERBB Family Members as Predictive Markers of Prostate Cancer Progression and Mortality.
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DOI：
10.3390/cancers13071688
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发表时间：
2021-04-02
期刊：
影响因子：
5.2
通讯作者：
Saad F
中科院分区：
文献类型：
--
作者：
Clairefond S;Ouellet V;Péant B;Barrès V;Karakiewicz PI;Mes-Masson AM;Saad F
诊断为前列腺癌的患者通常根据他们的Gleason评分，分期和前列腺特异性抗原（PSA）水平提供标准治疗计划。然而，对其他癌症的研究表明，除了临床和病理参数之外，还使用生物标志物来个性化治疗决策的重要性。考虑到局限性前列腺癌自然史的重要异质性，新的预后生物标志物将有助于患者分层和决策。在此，我们的研究表明ERBB家族的成员是对预测生化复发、转移发展甚至前列腺癌相关死亡率具有高预后价值的标志物。将这些标记物整合到临床实践中可能最终导致新诊断患者更合适的治疗决策，并可能降低前列腺癌的发病率和死亡率。背景：EGFR、ERBB 2、ERBB 3和ERBB 4是ERBB家族的生长受体，与上皮癌的发生有关。研究表明EGFR和ERBB 3在前列腺癌（PC）的发展中起作用，而ERBB 2和ERBB 4的参与尚不清楚。在这项研究中，我们评估了ERBB家族所有成员在来自一个大的队列的PC组织中的表达，并确定了它们单独或联合作为预后标志物的贡献。研究方法：使用免疫荧光结合数字图像分析，我们量化了EGFR，ERBB2，ERBB3和ERBB4在根治性乳腺癌切除术标本（n = 285）上的表达，这些标本排列在6个组织芯片上。通过在决策树模型中结合EGFR、ERBB2和ERBB3蛋白表达，我们确定了与生化复发（log rank = 25.295，p < 0.001）、骨转移发展（log rank = 23.228，p < 0.001）和癌症特异性死亡率（log rank = 24.586，p < 0.001）的相关性。结论：我们的研究表明，ERBB家族成员的特异性蛋白表达模式与PC进展和死亡风险增加相关。
Patients diagnosed with prostate cancer are usually offered a standard treatment plan based on their Gleason score, stage, and prostate-specific antigen (PSA) level. However, studies on other cancers have shown the importance of using biomarkers in addition to clinical and pathologic parameters to personalize therapeutic decisions. Given the important heterogeneity in the natural history of localized prostate cancer, novel prognostic biomarkers would aid in patient stratification and decision making. Here, our study shows that members of the ERBB family are markers that have high prognostic value for predicting biochemical relapse, metastasis development, and even prostate cancer-related mortality. The integration of these markers into clinical practice may eventually lead to more appropriate therapeutic decisions in newly diagnosed patients and potentially reduce prostate cancer morbidity and mortality. Background: EGFR, ERBB2, ERBB3, and ERBB4 are growth receptors of the ERBB family implicated in the development of epithelial cancers. Studies have suggested a role for EGFR and ERBB3 in the development of prostate cancer (PC), while the involvement of ERBB2 and ERBB4 remains unclear. In this study, we evaluated the expression of all members of the ERBB family in PC tissue from a large cohort and determined their contribution, alone or in combination, as prognostic markers. Methods: Using immunofluorescence coupled with digital image analyses, we quantified the expression of EGFR, ERBB2, ERBB3, and ERBB4 on radical prostatectomy specimens (n = 285) arrayed on six tissue microarrays. By combining EGFR, ERBB2, and ERBB3 protein expression in a decision tree model, we identified an association with biochemical recurrence (log rank = 25.295, p < 0.001), development of bone metastases (log rank = 23.228, p < 0.001), and cancer-specific mortality (log rank = 24.586, p < 0.001). Conclusions: Our study revealed that specific protein expression patterns of ERBB family members are associated with an increased risk of PC progression and mortality.
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影响因子：
3.7
作者：
Labouba I;Le Page C;Communal L;Kristessen T;You X;Péant B;Barrès V;Gannon PO;Mes-Masson AM;Saad F
通讯作者：
Saad F
DOI：
10.1186/s10020-018-0035-4
发表时间：
2018-06-27
期刊：
Molecular medicine (Cambridge, Mass.)
影响因子：
--
作者：
Mandel A;Larsson P;Sarwar M;Semenas J;Syed Khaja AS;Persson JL
通讯作者：
Persson JL
影响因子：
3.5
作者：
Fleischmann, Achim;Rocha, Carla;Thalmann, George N.
通讯作者：
Thalmann, George N.
影响因子：
5.2
作者：
Clairefond S;Péant B;Ouellet V;Barrès V;Tian Z;Trudel D;Karakiewicz PI;Mes-Masson AM;Saad F
通讯作者：
Saad F
影响因子：
11.5
作者：
Edwards, J;Traynor, P;Bartlett, JMS
通讯作者：
Bartlett, JMS