Cell fusion as a hidden force in tumor progression.
Cell fusion as a hidden force in tumor progression.
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DOI：
10.1158/0008-5472.can-09-2159
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发表时间：
2009-11-15
期刊：
影响因子：
11.2
通讯作者：
Kang Y
中科院分区：
文献类型：
--
作者：
Lu X;Kang Y
细胞融合在受精、胎盘、骨和肌肉组织的形成、免疫反应、组织修复和再生中起着至关重要的作用。在体细胞动力学中，细胞融合的认识不断提高，使细胞融合可能有助于癌症的发生和发展的百年假说重新焕发活力。在这篇综述中，我们讨论了实验和临床研究的结果，表明在肿瘤进展的不同阶段，包括非整倍体和肿瘤的起始，癌症干细胞的起源，多药耐药，和收购和转移能力的多样化的细胞融合的潜在多方面参与。
Cell fusion plays an essential role in fertilization, formation of placenta, bone and muscle tissues, immune response, tissue repair and regeneration. Increasing recognition of cell fusion in somatic cell dynamics has revitalized the century-old hypothesis that cell fusion may contribute to the initiation and progression of cancer. In this review, we discuss findings from experimental and clinical studies that suggest a potentially multifaceted involvement of cell fusion in different stages of tumor progression, including aneuploidy and tumor initiation, origin of cancer stem cells, multidrug resistance, and the acquisition and diversification of metastatic abilities.