Motor Unit Number Reductions in Paretic Muscles of Stroke Survivors
Motor Unit Number Reductions in Paretic Muscles of Stroke Survivors
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DOI：
10.1109/titb.2011.2140379
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发表时间：
2011-07-01
影响因子：
--
通讯作者：
Zhou, Ping
中科院分区：
文献类型：
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作者：
Li, Xiaoyan;Wang, Ying-Chih;Zhou, Ping
本研究的目的是评估是否有证据表明，在中风幸存者的轻瘫肌肉的脊髓运动神经元损失，使用一个指数测量称为运动单位数量指数（MUNIX）。MUNIX是最近发展起来的一种新的神经生理学技术，它提供了一个与肌肉中运动单位数量成比例的指数，但不一定是精确的绝对计数。MUNIX技术应用于第一背侧骨间肌（FDI）的双边在9个中风受试者。采用最大M波的面积和功率以及不同收缩水平下的干扰型肌电图（EMG）计算MUNIX。还使用最大M波记录和MUNIX值计算运动单位大小指数（MUSizeIndex）。我们观察到的最大M波振幅和MUNIX值的麻痹FDI肌肉，与对侧肌肉相比，显着降低。在所有受试者中，麻痹肌肉的最大M波振幅为6.4 ± 2.3 mV，对侧肌肉为9.7 ± 2.0 mV（p < 0.001）。这些测量结合自主EMG记录，导致麻痹肌肉的MUNIX值为109 +/- 53，远低于对侧肌肉的MUNIX值153 +/- 38（p < 0.01）。麻痹侧和对侧肌肉的MUSize指数值无显著差异。然而，轻瘫肌肉的MUSize指数值的范围（48.8-93.3 μ V）比对侧肌肉（51.7-84.4 μ V）略宽。从指数测量的结果提供了进一步的证据脊髓运动神经元损失后，半球脑损伤。
The objective of this study is to assess whether there is evidence of spinal motoneuron loss in paretic muscles of stroke survivors, using an index measurement called motor unit number index (MUNIX). MUNIX, a recently developed novel neurophysiological technique, provides an index proportional to the number of motor units in a muscle, but not necessarily an accurate absolute count. The MUNIX technique was applied to the first dorsal interosseous (FDI) muscle bilaterally in nine stroke subjects. The area and power of the maximum M-wave and the interference pattern electromyogram (EMG) at different contraction levels were used to calculate the MUNIX. A motor unit size index (MUSizeIndex) was also calculated using maximum M-wave recording and the MUNIX values. We observed a significant decrease in both maximum M-wave amplitude and MUNIX values in the paretic FDI muscles, as compared with the contralateral muscles. Across all subjects, the maximum M-wave amplitude was 6.4 +/- 2.3 mV for the paretic muscles and 9.7 +/- 2.0 mV for the contralateral muscles (p < 0.001). These measurements, in combination with voluntary EMG recordings, resulted in the MUNIX value of 109 +/- 53 for the paretic muscles, much lower than the MUNIX value of 153 +/- 38 for the contralateral muscles (p < 0.01). No significant difference was found in MUSizeIndex values between the paretic and contralateral muscles. However, the range of MUSizeIndex values was slightly wider for paretic muscles (48.8-93.3 mu V) than the contralateral muscles (51.7-84.4 mu V). The findings from the index measurements provide further evidence of spinal motoneuron loss after a hemispheric brain lesion.