Increase in serum adiponectin concentration in patients with heart failure and cachexia: relationship with leptin, other cytokines, and B-type natriuretic peptide
Increase in serum adiponectin concentration in patients with heart failure and cachexia: relationship with leptin, other cytokines, and B-type natriuretic peptide
复制标题
DOI：
10.1093/eurheartj/ehm033
复制
发表时间：
2007-04-01
影响因子：
39.3
通讯作者：
McMurray, John J. V.
中科院分区：
文献类型：
--
作者：
McEntegart, Margaret B.;Awede, Bonaventure;McMurray, John J. V.
脂联素是一种脂肪源性激素，参与机体代谢的调节。脂联素浓度与体重呈负相关，并且在动物中导致体重减轻。方法和结果测定三组冠心病患者血清脂联素浓度：（i）HF，左室收缩功能减退，恶病质组（n = 10），（ii）HF，左室收缩功能减退，但无恶病质组（n = 20），（iii）HF，左室收缩功能减退，但无恶病质组（n = 10），（iv）HF，左室收缩功能减退，但无恶病质组（n = 20），（iv）HF，左室收缩功能减退，但无恶病质组（n = 20），（iv）HF，左室收缩功能减退，但无恶病质组（n = 20），（iv）HF，左室收缩功能减退，但无恶病质组（n = 20）。（iii）HF对照-患有CAD、无HF且保留收缩功能的患者（n = 10）;以及健康对照组（n = 7）。HF和恶病质患者的脂联素浓度[23.8（10.2-37.2）μ g/mL]高于所有其他组：HF-无恶病质组8.1（0.5-16.6）μ g/mL; CAD-对照组7.1（0.4-13.5）μ g/mL;健康对照组8.7（2.5-16.8）μ g/mL）（每次比较P < 0.05）。脂联素水平与体重指数、体脂百分比、腰围、胰岛素抵抗呈负相关，与B型利钠肽（BNP）、肿瘤坏死因子-α呈正相关。这可能代表了对体脂变化的生理反应的保留，但也可能表明脂联素在恶病质的发病机制中起作用。BNP和脂联素之间的相关性也增加了前者可能增加后者分泌的可能性。
Aims Adiponectin is a fat-derived hormone involved in the regulation of metabolism. Adiponectin concentration is inversely related to body weight and, in animals, causes weight loss. We, therefore, measured adiponectin concentration in patients with heart failure (HF) and cachexia.Methods and results Serum adiponectin concentrations were measured in three groups of patients with coronary artery disease (CAD): (i) HF, reduced left ventricular systolic function, and cachexia (n = 10); (ii) HF, reduced systolic function but no cachexia (n = 20); (iii) HF-controls-patients with CAD, no HF, and preserved systolic function (n = 10); and in a healthy control group (n = 7). Patients with HF and cachexia had higher concentrations of adiponectin [23.8 (10.2-37.2) mu g/mL] than all other groups: HF-no cachexia 8.1 (0.5-16.6) mu g/mL; CAD-controls 7.1 (0.4-13.5) mu g/mL; and healthy controls 8.7 (2.5-16.8) mu g/mL) (P < 0.05 for each comparison). Adiponectin correlated negatively with body mass index, percentage of body fat, waist circumference and insulin resistance, and positively with B-type natriuretic peptide (BNP) and tumour necrosis factor-alpha.Conclusion Cachexia in HF is associated with an increase in adiponectin concentration. This may represent preservation of the physiological response to change in body fat but might also suggest that adiponectin plays a rote in the pathogenesis of cachexia. The correlation between BNP and adiponectin also raises the possibility that the former might increase the secretion of the latter.