Organic base-promoted efficient dehydrogenative/decarboxylative aromatization of tetrahydro-b-carbolines into b-carbolines under air
Organic base-promoted efficient dehydrogenative/decarboxylative aromatization of tetrahydro-b-carbolines into b-carbolines under air
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有机碱促进空气下四氢-b-咔啉高效脱氢/脱羧芳构化为b-咔啉
DOI：
10.1016/j.tetlet.2019.02.020
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发表时间：
2019
影响因子：
1.8
通讯作者：
Dongyin Chen
中科院分区：
文献类型：
--
作者：
Ziquan Zhao;Yan Sun;Lilin Wang;Xuan Chen;Yanpei Sun;Long Lin;Yulin Tang;Fei Li;Dongyin Chen
有机碱DBN已被认为是一种有效的试剂，可以在空气气氛下促进四氢-b-碳氢化合物的脱氢/脱羧基芳构化反应，从而以中到好的产率获得相应的b-碳氢化合物。该方法在生物碱类化合物b-Caroline的克级合成中的应用也被证明。
Organic base DBN has been identified as an efficient reagent for promoting the dehydrogenative/decarboxylative aromatization of tetrahydro-b-carbolines under air atmosphere, to access the corresponding.b-carbolines in moderate to good yields. The utility of this protocol for the gram-scale synthesis of b-carboline alkaloids eudistomin U (7) and harmane (10) has also been demonstrated.